Investigating the Geometry and Mechanical Properties of Human Round Window Membranes Using Micro-Fringe Projection
Investigating the Geometry and Mechanical Properties of Human Round Window Membranes Using Micro-Fringe Projection
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DOI：
10.1097/mao.0000000000002911
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发表时间：
2020-12
影响因子：
2.1
通讯作者：
Junfeng Liang;Don U. Nakmali;R. Gan;Hongbing Lu;C. Dai
中科院分区：
文献类型：
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作者：
Junfeng Liang;Don U. Nakmali;R. Gan;Hongbing Lu;C. Dai
假设：圆窗膜的几何形状和力学性能对耳蜗器的功能有根本的影响。背景：了解RWM的力学行为对人工耳蜗术和人工耳蜗术后的设计具有重要意义。尽管在文献中对RWM的解剖学进行了广泛的研究和描述，但关于RWM的真实形状仍然存在争议。由于小尺寸RWM的测量困难，RWM的力学性能也鲜有报道。方法：采用显微条纹投影法重建14个RWM的三维几何结构。随后利用有限元模型和逆方法对RWM的力学性能进行了测量。从显微条纹投影重建的三维表面形貌和两个主要方向的曲率在样品之间都表现出很大的差异。结果：RWM直径为1.6 5~2.2 mm，曲率为−0.97~3.76 mm−1。结论：本工作测量的人RWM的几何结构和力学性能可应用于手术设计和耳蜗骨模型分析。
Hypothesis: The geometry and the mechanical property of the round window membrane (RWM) have a fundamental impact on the function of cochlea. Background: Understanding the mechanical behavior of RWM is important for cochlear surgery and design for the cochlear implant. Although the anatomy of RWM has been widely studied and described in the literature, argument remains regarding the true shape of RWM. The mechanical properties of RWM are also scarcely reported due to the difficulty of the measurement of the small size RWM. Methods: In this paper, micro-fringe projection was used to reconstruct the 3-dimensional geometries of 14 RWMs. Mechanical properties of the RWMs were subsequently measured using finite element (FE) model and an inverse method. The three-dimensional surface topographies and the curvatures of the two major directions reconstructed from the micro-fringe projection both demonstrated wide variations among samples. Results: The diameters of the RWMs vary from 1.65 to 2.2 mm and the curvatures vary from −0.97 to 3.76 mm−1. The nonlinear elasticity parameters in the Ogden model for each sample was measured and the average effective Young's modulus is approximately 1.98 MPa. Conclusion: The geometries and mechanical properties of the human RWM measured in the work could potentially be applied to surgery design and on modeling analysis for the cochlea.