The importance of anaemia in diagnosing colorectal cancer: a case-control study using electronic primary care records
The importance of anaemia in diagnosing colorectal cancer: a case-control study using electronic primary care records
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DOI：
10.1038/sj.bjc.6604165
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发表时间：
2008-01-22
影响因子：
8.8
通讯作者：
Marshall, T.
中科院分区：
文献类型：
--
作者：
Hamilton, W.;Lancashire, R.;Marshall, T.
虽然贫血被认为是结直肠癌的一个特征，但确切的风险尚不清楚。我们进行了一项病例对照研究，使用电子初级保健记录从健康改善网络数据库，英国。共有6442例患者被诊断为结直肠癌，并与45066例对照组在年龄，性别和实践方面相匹配。我们计算了1g dl（-1）血红蛋白和10岁年龄段的男女结直肠癌的似然比和阳性预测值，并检查了铁缺乏的特征。在男性中，3421例病例中有178例（5.2%）和23928例对照中有47例（0.2%）有血红蛋白
Although anaemia is recognised as a feature of colorectal cancer, the precise risk is unknown. We performed a case-control study using electronic primary care records from the Health Improvement Network database, UK. A total of 6442 patients had a diagnosis of colorectal cancer, and were matched to 45 066 controls on age, sex, and practice. We calculated likelihood ratios and positive predictive values for colorectal cancer in both sexes across 1 g dl(-1) haemoglobin and 10-year age bands, and examined the features of iron deficiency. In men, 178 (5.2%) of 3421 cases and 47 (0.2%) of 23 928 controls had a haemoglobin