The incidence of cognitive decline after (not) undergoing coronary artery bypass grafting: the impact of a controlled definition
The incidence of cognitive decline after (not) undergoing coronary artery bypass grafting: the impact of a controlled definition
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DOI：
10.1111/j.1399-6576.2005.00835.x
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发表时间：
2005-10-01
影响因子：
2.1
通讯作者：
van Dijk, D
中科院分区：
文献类型：
--
作者：
Keizer, AMA;Hijman, R;van Dijk, D
背景：据报道，冠状动脉旁路移植术（CABG）后，20-30%的患者患有认知功能下降。这些高发病率的研究报告，但是，没有包括一个适当的control group.Methods：我们反复进行了一系列的神经心理测试，112名健康的中年志愿者不接受手术，并应用两个广泛使用的认知能力下降的定义，他们的测试结果。此外，我们重新分析了281名CABG患者的神经心理学测试数据，其中认知功能下降的定义考虑到了在志愿者中发现的测试性能的自然变异性。结果：在首次评估后3个月，14-28%的志愿者根据CABG后认知功能下降的定义患有认知功能下降。使用控制的认知功能下降的定义，考虑到测试性能的自然变异，我们发现，只有7.7%的CABG患者患有认知功能下降，在3个月后，他们operation.Conclusion：这些数据表明，认知功能障碍的发病率CABG后，以前被大大高估。
Background: After coronary artery bypass grafting (CABG), 20-30% of patients are reported to suffer from cognitive decline. Studies reporting these high incidences, however, have not included an appropriate control group.Methods: We repeatedly administered a series of neuropsychological tests to 112 healthy middle-aged volunteers not undergoing surgery, and applied two widely used definitions of cognitive decline to their test results. In addition, we re-analysed the neuropsychological test data of 281 CABG patients with a definition of cognitive decline that takes into account the natural variability of test performance that was found in the volunteers.Reuslts: Three months after their first assessment, 14-28% of the volunteers suffered from cognitive decline according to the definitions of cognitive decline after CABG. Using the controlled definition of cognitive decline that takes the natural variability in test performance into account, we found that only 7.7% of the CABG patients suffered from cognitive decline at 3 months after their operation.Conclusion: These data suggest that the incidence of cognitive dysfunction after CABG has previously been greatly overestimated.