Renal kallikrein-kinin system.
Renal kallikrein-kinin system.
复制标题
肾激肽释放酶-激肽系统。
DOI：
10.1038/ki.1986.14
复制
发表时间：
1986
影响因子：
19.6
通讯作者：
Carretero,OA
中科院分区：
文献类型：
--
作者：
Scicli,AG;Carretero,OA
虽然肾脏的主要功能是调节体液的容量和离子组成，但它也是一个内分泌器官，在血压调节中具有重要作用。一些肾脏激素同时具有血管收缩和抗尿钠排泄作用（血管加压系统），而另一些则具有血管扩张和利尿钠排泄作用（血管减压系统）。这些系统的一个特点是它们不仅作用于远处的靶器官，而且作用于肾脏本身（局部激素或自体激素）。例如，肾素-血管紧张素、前列腺素和激肽释放酶-激肽系统，其激活和作用似乎是相互关联的，可能不仅通过改变肾外血管的张力，而且还通过直接调节肾内钠和水的排泄，或许通过调节肾血流分布来参与血压的控制。肾激肽释放酶-激肽系统是这些系统中定义最不明确的，但它与肾血流的控制有关。高血压、巴特综合征和肾脏疾病的发病机制，以及利尿剂和血管紧张素 I 转换酶抑制剂等药物的降压机制。然而，肾激肽释放酶-激肽系统在这些正常和病理条件下的明确作用仍然未知。
Although the primary function of the kidney is regulation of the volume and ionic composition of body fluids, it is also an endocrine organ with an important role in the regulation of blood pressure. Some renal hormones have both vasoconstrictor and antinatriuretic effects (vasopressor systems) while others have vasodilator and natriuretic effects (vasodepressor systems). A characteristic of these systems is that they act not only on distant target organs but also in the kidney itself (local hormones or autacoids). For example, the renin-angiotensin, prostaglandin, and kallikrein-kinin systems, whose activation and actions appear to be interrelated, may participate in the control of blood pressure not only by altering the tone of extrarenal blood vessels, but also by directly regulating intra-renal sodium and water excretion, perhaps by regulating renal blood flow distribution.The renal kallikrein-kinin system is the least well defined of these systems, yet it has been implicated in the control of renal blood flow and function, in the pathogenesis of hypertension, Bartter syndrome, and renal diseases, and in the antihypertensive mechanism of drugs such as diuretics and angiotensin I converting enzyme inhibitors. However, the unequivocal role of the renal kallikrein-kinin system in these normal and pathological conditions still remains unknown.