Undifferentiated (anaplastic) carcinoma of the pancreas showing sarcomatous change and neoplastic cyst formation
Undifferentiated (anaplastic) carcinoma of the pancreas showing sarcomatous change and neoplastic cyst formation
复制标题
胰腺未分化（间变）癌显示肉瘤性改变和肿瘤性囊肿形成
DOI：
10.1007/bf02821610
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
N. Sawabu
中科院分区：
文献类型：
--
作者：
Y. Motoo;A. Kawashima;H. Watanabe;S. Su;T. Okai;N. Sawabu
结论胰腺未分化癌包括梭形细胞型肉瘤样改变和肿瘤性囊肿。免疫组化分析表明，肉瘤和囊性部分的上皮起源。本例表现为肉瘤样变和囊性变的“双重”分化。背景胰腺肉瘤或肉瘤样变很常见。肉瘤样改变的起源尚不清楚。另一方面，胰腺癌有时会显示坏死，并在其生长过程中形成一个囊性病变，但肿瘤性囊肿形成是非常罕见的，除了cystadenomas.MethodsWe报告一例胰腺未分化（间变性）癌与肉瘤的变化和肿瘤性囊肿形成。临床病理和免疫组化分析performed.ResultsA 75岁的男性被录取，因为腰痛和体重减轻。入院后7天因梗阻性黄疸死亡。尸体剖检发现此大肿块为低分化导管腺癌，主要由梭形细胞型肉瘤组成。囊性病变是一种肿瘤性囊肿，囊壁由上皮肿瘤细胞组成。囊腔内无坏死或出血。免疫组化分析显示，肿瘤和囊性病变的上皮起源。在肝脏和淋巴结的转移灶中也发现了肉瘤样变化。该肿瘤被认为是标记为未分化（间变性）的胰腺癌。
SummaryConclusionPancreatic undifferentiated (anaplastic) carcinoma contained two components: sarcomatous change of spindle-cell type and a neoplastic cyst. Immunohistochemical analysis suggested that both the sarcomatous and the cystic portions were of epithelial origin. This case showed a “dual” differentiation both into the sarcomatous change and into the cystic lesion.BackgroundPancreatic sarcoma or sarcomatous change is very rate. The origin of the sarcomatous change is unknown. On the other hand, pancreatic adenocarcinoma sometimes shows necrosis and forms a cystic lesion during its growth, but a neoplastic cyst formation is very rare except for cystadenomas.MethodsWe report a case of pancreatic undifferentiated (anaplastic) carcinoma associated with sarcomatous change and neoplastic cyst formation. Clinicopathological and immunohistochemical analyses were performed.ResultsA 75-yr-old male was admitted because of low back pain and body weight loss. He died 7 d after admission presenting obstructive jaundice. Autopsy disclosed that the large mass was a poorly differentiated ductal adenocarcinoma, which mostly consisted of sarcomatous components of spindle-cell type. The cystic lesion was a neoplastic cyst with the wall composed of epithelial tumor cells. There was no necrosis or hemorrhage in the cystic cavity. Immunohistochemical analyses suggested that both the tumor and the cystic lesion were of epithelial origin. Sarcomatous changes were recognized also in the metastatic lesions in the liver and lymph nodes. The tumor is considered to be labeled undifferentiated (anaplastic) carcinoma of the pancreas.