High-dose intra-arterial cisplatin therapy followed by radiation therapy for advanced squamous cell carcinoma of the head and neck.
High-dose intra-arterial cisplatin therapy followed by radiation therapy for advanced squamous cell carcinoma of the head and neck.
复制标题
高剂量动脉内顺铂治疗，随后进行放射治疗，治疗晚期头颈部鳞状细胞癌。
DOI：
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复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
W. Bank
中科院分区：
文献类型：
--
作者：
W. R. Wilson;R. Siegel;L. Harisiadis;David Davis;Hoang Nguyen;W. Bank
目的
评估由4个周期的高剂量顺铂动脉内输注和随后的放射治疗组成的方案在晚期未经治疗和既往接受过治疗的头颈部鳞状细胞癌患者中改善化疗反应率、器官保护和生存率的有效性。
设计和设置
一项对在学术医学中心接受治疗的序贯入组患者的前瞻性研究。生存分析采用Kaplan-Meier法。
患者
58例年龄≥ 18岁的非妊娠成人，患有可测量的未经治疗或经活检证实的复发性晚期头颈部鳞状细胞癌。
主要观察指标
靶向动脉内顺铂输注的反应率、器官保存和生存率。
结果
58例患者（44例男性和14例女性）随访至少2年（中位随访时间为27个月）。43例既往未经治疗的患者中有29例（67%）对动脉内顺铂治疗有完全反应。在未接受治疗的患者中，28名患者在中位随访时间30个月后存活且无疾病。5例复发性疾病患者对动脉内顺铂治疗完全缓解。中位随访时间为17.5个月后，有4名幸存者。值得注意的是，两组均未发生与治疗相关的死亡或严重并发症。
结论
高剂量动脉内顺铂治疗提供了高的完全和部分缓解率（91%）。高剂量动脉内顺铂联合放射治疗可有效提高既往未经治疗的晚期头颈部鳞状细胞癌患者的生存率和器官保存率。这种治疗方案对复发性疾病的效果要差得多。
OBJECTIVE
To assess the effectiveness of a protocol consisting of 4 cycles of high-dose intra-arterial cisplatin infusions followed by radiation therapy for improving chemotherapy response rates, organ preservation, and survival in patients with advanced-stage untreated and previously treated squamous cell carcinoma of the head and neck.
DESIGN AND SETTING
A prospective study of sequentially enrolled patients treated in an academic medical center. The Kaplan-Meier method was used for survival analysis.
PATIENTS
Fifty-eight nonpregnant adults, 18 years of age or older, with measurable untreated or recurrent advanced biopsy-proven squamous cell carcinoma of the head and neck.
MAIN OUTCOME MEASURES
Response rate to targeted intra-arterial cisplatin infusions, organ preservation, and survival.
RESULTS
Fifty-eight patients (44 men and 14 women) were followed up for at least 2 years (median duration of follow-up, 27 months). Twenty-nine (67%) of the 43 previously untreated patients had a complete response to intra-arterial cisplatin therapy. Of the untreated patients, 28 are alive and disease free after a median follow-up time of 30 months. Five of the patients with recurrent disease had a complete response to intra-arterial cisplatin therapy. There were 4 survivors after a median follow-up time of 17.5 months. Of note, there were no deaths or serious complications related to the treatment in either group.
CONCLUSIONS
High-dose intra-arterial cisplatin therapy provides a high complete and partial response rate (91%). The combination of high-dose intra-arterial cisplatin and radiation therapy is effective in improving survival and organ preservation rates in patients with previously untreated, advanced squamous cell carcinoma of the head and neck. This treatment protocol is much less effective for recurrent disease.
头颈部晚期鳞状细胞癌的同步加强放疗。
DOI：
10.1016/s0167-8140(85)80055-4
发表时间：
1985
期刊：
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
影响因子：
--
作者：
Knee,R;Fields,RS;Peters,LJ
通讯作者：
Peters,LJ
影响因子：
45.3
作者：
Al-Sarraf, M;LeBlanc, M;Ensley, JF
通讯作者：
Ensley, JF