Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?
Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?
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DOI：
10.1158/1078-0432.ccr-09-2943
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发表时间：
2010-06-15
影响因子：
11.5
通讯作者：
Kahn, Michael
中科院分区：
文献类型：
--
作者：
Takahashi-Yanaga, Fumi;Kahn, Michael
Wnt信号通路在进化过程中一直是保守的，在胚胎发育过程中调节细胞增殖、形态、运动和命运。这些通路在整个成年期也通过调节体干细胞及其微环境在维持包括皮肤、血液、肠道和大脑在内的组织内稳态方面发挥重要作用。Wnt通路的异常调节会导致这些相同组织中的肿瘤性增殖。有人提出，Wnt信号也参与癌症干细胞（CSC）的调节，因为调节正常成体干细胞和CSC的信号通路有许多相似之处。在本综述中，我们重点关注Wnt/β -连环蛋白信号通路，它是研究最为深入且特征最为明确的Wnt信号通路。我们概述了Wnt/β -连环蛋白信号通路在CSC中的功能，以及开发针对该通路的新型疗法的可能性。《临床癌症研究》；16(12)；3153 - 62。（C）2010美国癌症研究协会。
The Wnt signaling pathways have been conserved throughout evolution and regulate cell proliferation, morphology, motility, and fate during embryonic development. These pathways also play important roles throughout adult life to maintain homeostasis of tissues including skin, blood, intestine, and brain by regulating somatic stem cells and their niches. Aberrant regulation of the Wnt pathway leads to neoplastic proliferation in these same tissues. It has been suggested that Wnt signaling is also involved in the regulation of cancer stem cells ( CSC), because there are many similarities in the signaling pathways that regulate normal adult stem cells and CSC. In this Perspective, we have focused on the Wnt/beta-catenin signaling pathway, which is the most intensively studied and best characterized Wnt signaling pathway. We provide an overview on the function of the Wnt/beta-catenin signaling pathway in CSC, and the possibility of the development of novel therapeutics to target this pathway. Clin Cancer Res; 16( 12); 3153-62. (C)2010 AACR.