Biodegradation of microcystin-LR by indigenous mixed bacterial populations
Biodegradation of microcystin-LR by indigenous mixed bacterial populations
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DOI：
10.1016/0043-1354(95)00189-1
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发表时间：
1996-02-01
期刊：
影响因子：
12.8
通讯作者：
Sutton, A
中科院分区：
文献类型：
--
作者：
Cousins, IT;Bealing, DJ;Sutton, A
微囊藻毒素-LR是一种强效的哺乳动物毒素，已知它是造成家养动物死亡的原因，因此人们对其环境归宿感到关切。在实验室进行的实验中，使用低水平（10微克升（-1））的水库水微囊藻毒素-LR，毒素的主要生物降解发生在不到1周。一项旨在确定微囊藻毒素-LR矿化程度的实验，在有氧条件下使用天然微生物种群，表明肽环似乎对生物降解具有相当的抗性，因为矿化程度不高。然而，由于微囊藻毒素LR的毒性严重依赖于肽环相对于“Adda”（蓝绿藻毒素特有的β-氨基酸）侧链的方向，并且似乎该侧链在生物降解过程中受到影响，因此似乎可能发生毒性降低。
Microcystin-LR is a potent mammalian toxin which is known to have been responsible for the deaths of domesticated animals, and consequently there is concern as to its environmental fate. In laboratory experiments conducted using low levels (10 mu g l(-1)) of microcystin-LR in reservoir water, primary biodegradation of the toxin was shown to occur in less than 1 week. An experiment designed to ascertain the degree of mineralisation of microcystin-LR, using natural microbial populations under aerobic conditions, showed that the peptide ring appears to be fairly resistant to biodegradation, as the degree of mineralisation was not high. However, as the toxicity of microcystin LR is critically dependent on the orientation of the peptide ring with respect to the ''Adda'' (the beta-amino acid which is unique to the blue-green algal toxins) side-chain, and it appears that this side chain is affected during biodegradation, it seems likely that a reduction in toxicity occurs.