The intracrine renin-angiotensin system.
The intracrine renin-angiotensin system.
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DOI：
10.1042/cs20120089
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Baker KM
中科院分区：
文献类型：
--
作者：
Kumar R;Thomas CM;Yong QC;Chen W;Baker KM
肾素-血管紧张素系统(RAS)是最早也是研究最广泛的激素系统之一。RAS在几个方面都是一种非典型的激素系统。该系统的主要生物活性多肽，血管紧张素(Ang)II，既不是在一个特定的器官中合成的，也不是针对一个特定的器官。新的研究发现了更多具有重要生理和病理作用的多肽。更多的多肽也意味着产生这些多肽的更新的酶促级联反应，以及更多的介导这一功能的受体。此外，组成RAS的成分的完全不同的作用已被发现，例如通过Prorenin受体对Prorenin的作用。组织中存在独立于内分泌系统、以自分泌/旁分泌方式发挥作用的子系统，进一步增加了RAS的复杂性。RAS似乎在细胞水平上是相关的，其中单个细胞有一个完整的系统，称为细胞内RAS。因此，从细胞到组织再到整个生物体，RAS表现出连续性，同时在不同的水平上保持独立的控制。细胞内RAS对于RAS来说是一个相对较新的概念。现对该系统在不同组织中的研究文献进行综述。
The renin-angiotensin system (RAS) is one of the earliest and most extensively studied hormonal systems. The RAS is an atypical hormonal system in several ways. The major bioactive peptide of the system, angiotensin (Ang) II, is neither synthesized in, nor targets one specific organ. New research has identified additional peptides with important physiological and pathological roles. More peptides also mean newer enzymatic cascades that generate these peptides and more receptors that mediate the function. In addition, completely different roles of components that constitute the RAS have been uncovered, such as that for prorenin via the prorenin receptor. Complexity of the RAS is further enhanced by the presence of sub-systems in tissues, which act in an autocrine/paracrine manner independent of the endocrine system. The RAS seems relevant at the cellular level, wherein individual cells have a complete system, termed the intracellular RAS. Thus, from cells to tissues to the entire organism, the RAS exhibits continuity while maintaining independent control at different levels. The intracellular RAS is a relatively new concept for the RAS. The current review presents a synopsis of the literature on this system in different tissues.