Novel spatiotemporal patterns of epithelial tumor invasion in Drosophila discs large egg chambers
Novel spatiotemporal patterns of epithelial tumor invasion in Drosophila discs large egg chambers
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DOI：
10.1002/dvdy.20336
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发表时间：
2005-03-01
影响因子：
2.5
通讯作者：
Kishore, S
中科院分区：
文献类型：
--
作者：
Goode, S;Wei, J;Kishore, S
果蝇早期卵腔中的椎间盘缺失（Dlg）导致肿瘤滤泡细胞从前上皮侵入，这种模式类似于卵子发生中期的发育边缘细胞迁移。在这里，我们分析了dlg入侵的新的空间和时间模式。尽管Dlg在所有卵泡细胞中普遍表达，但侵袭偏向于前端和后端。与卵室中央区域相比，侵袭的模式与较高的卵泡细胞增殖率和较高的上皮极性丧失频率相关。尽管如此，从终末与中心区域的每次侵袭事件侵袭的细胞的平均数量大致相等。有趣的是，dlg侵袭的模式似乎与负责前后模式的原癌基因信号建立的边界一致。因此，果蝇卵室可能是一个有用的模型，探索上皮肿瘤的侵袭可能是一个新形态发生的过程中组织的发育模式形成所必需的信号。(C)2005 Wiley-Liss，Inc.
Loss of Discslarge (Dlg) in early Drosophila egg chambers causes invasion of tumor follicle cells from the anterior epithelium, a pattern that resembles developmental border cell migration dining mid-oogenesis. Here, we have analyzed novel spatial and temporal patterns of dlg invasion. Even though Dlg is ubiquitously expressed in all follicle cells, invasions are biased at the anterior and posterior termini. The patterns of invasion correlate with both a higher rate of follicle cell proliferation and with a greater frequency of loss of epithelial polarity at the termini compared with central regions of the egg chamber. Nonetheless, the average number of cells that invade per invasion event from terminal vs. central regions is approximately equal. Of interest, patterns of dlg invasion appear to coincide with boundaries established by proto-oncogene signals responsible for anterior-posterior patterning. The Drosophila egg chamber may thus be a useful model for exploring how epithelial tumor invasion might be a neomorphogenetic process organized by signals essential for developmental pattern formation. (C) 2005 Wiley-Liss, Inc.