Implantable Microimaging Device for Observing Brain Activities of Rodents
Implantable Microimaging Device for Observing Brain Activities of Rodents
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DOI：
10.1109/jproc.2016.2585585
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发表时间：
2017-01-01
影响因子：
20.6
通讯作者：
Akay, Metin
中科院分区：
文献类型：
--
作者：
Ohta, Jun;Ohta, Yasumi;Akay, Metin
本文介绍了一种用于观察小鼠、大鼠等小型实验动物脑活动的植入式微成像装置。这类设备分为三类：光纤系统、头戴式荧光显微镜和可直接植入大脑的超小型图像传感器。其中，我们重点关注第三个，因为这是探索自由运动小鼠脑深部活动的有力工具。以小鼠脑深部图像为例，说明了该装置的结构和性能。
In this review, we present an implantable microimaging device to observe brain activities of small experimental animals such as mice and rats. Three categories of such devices are described: an optical fiber system, a head-mountable fluorescent microscope, and an ultrasmall image sensor that can be directly implanted into the brain. Among them, we focus on the third one, because this is a powerful tool to explore brain activities in deep brain region in a freely moving mouse. The device structure and performance are shown with some examples of deep brain images of mice.