Efficient method for nuclear reprogramming
Efficient method for nuclear reprogramming
复制标题
作者：
신야 야마나까;미치요 고야나기
本发明提供了一种制造干细胞的有效方法，可能是人造细胞，在miRNA存在的情况下，由核初始化参数启动成核的步骤，并且在miRNA中(a)胚胎干细胞比体细胞高表达，并且(b)提供了一种在miRNA存在的情况下的miRNA方法，该miRNA具有比在没有miRNA的情况下提供高核初始化效率的特性。胚胎干细胞，miRNA，人工多能干细胞，细胞核初始化
The present invention provides a efficient method of manufacturing the stem likely the artificial cells, a step of nucleation initiated by a nuclear initialization parameter in the presence of a miRNA and, being in the miRNA is (a) embryonic stem cells highly expressed than somatic cell, and (b ) provides a method of miRNA in the presence of the miRNA having a property of providing a high nucleus initialization efficiency than in the absence of the miRNA. Embryonic stem cells, miRNA, artificial pluripotent stem cells, the nucleus initialization