CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions
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DOI：
10.4049/jimmunol.175.3.1558
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发表时间：
2005-08-01
影响因子：
4.4
通讯作者：
Kuchroo, VK
中科院分区：
文献类型：
--
作者：
Dardalhon, V;Schubart, AS;Kuchroo, VK
在Th1和Th2细胞上差异表达的表面分子可用于调节体内特异性免疫应答。使用一组单克隆抗体，我们已经确定了小鼠CD226特异性表达的分化的Th1细胞的表面上，但不是Th2或Th0细胞。虽然CD226在CD8细胞上组成型表达，但在活化后在CD4细胞上上调。Th1分化导致CD226表达增强，而表达在Th2极化后下调。我们证明，CD226参与调节T细胞活化，在体内治疗抗CD226的结果微不足道的减少Th1细胞的扩增和诱导的APC，抑制T细胞活化。此外，抗CD226治疗延迟了Th1介导的自身免疫性疾病（实验性自身免疫性脑脊髓炎）的发作并降低了其严重程度。我们的数据表明，CD226是一种共刺激分子，在Th1细胞的激活和效应功能中起着重要作用。
Surface molecules that are differentially expressed on Th1 and Th2 cells may be useful in regulating specific immune responses in vivo. Using a panel of mAbs, we have identified murine CD226 as specifically expressed on the surface of differentiated Th1 cells but not Th2 or Th0 cells. Although CD226 is constitutively expressed on CD8 cells, it is up-regulated on CD4 cells upon activation. Th1 differentiation results in enhanced CD226 expression, whereas expression is down-regulated upon Th2 polarization. We demonstrate that CD226 is involved in the regulation of T cell activation; in vivo treatment with anti-CD226 results insignificant reduction of Th1 cell expansion and in the induction of APCs that inhibit T cell activation. Furthermore, anti-CD226 treatment delays the onset and reduces the severity of a Th1-mediated autoinmume disease, experimental autoimmune encephalomyelitis. Our data suggest that CD226 is a costimulatory molecule that plays an important role in activation and effector functions of Th1 cells.