ONTOGENY OF LATERAL PREOPTIC UNIT-ACTIVITY IN RATS
ONTOGENY OF LATERAL PREOPTIC UNIT-ACTIVITY IN RATS
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DOI：
10.1016/0361-9230(79)90011-x
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发表时间：
1979-01-01
影响因子：
3.8
通讯作者：
MCMULLEN, NT
中科院分区：
文献类型：
--
作者：
ALMLI, CR;MCMULLEN, NT
从1日龄至31日龄（断奶后）的幼鼠外侧视前区（LPO）内的单位进行细胞外单单位记录。用dial-urethane麻醉大鼠，记录10-20分钟的基础（自发）尖峰率。大鼠还接受了疼痛唤醒刺激（夹尾和s.c.注射福尔马林溶液）和渗透刺激（s.c.或i.p.注射高渗氯化钠或蔗糖溶液）。新生大鼠LPO细胞自发活跃；基穗率在发育过程中增加。在发育过程中，LPO单位的百分比增加，在高渗注射（渗透敏感）的反应中显示出尖峰率的改变。所有年龄的LPO单位都对剧烈的疼痛唤醒刺激有反应。LPO单位活性特征的发育变化与LPO神经元的形态发育和渗透诱导饮酒行为的发展是平行的。
Extracellular single unit recordings were made from units within the lateral preoptic area (LPO) of infant rats from 1 day of age through 31 days of age (postweaning). The rats were anesthetized with dial-urethane and basal (spontaneous) spike rates were recorded for 10-20 min. The rats also received pain-arousal stimulation (tail-pinch and s.c. injection of formalin solution), and osmotic stimulation (s.c. or i.p. injection of hyperosmotic NaCl or sucrose solutions). LPO units were spontaneously active in neonatal rats; basal spike rates increased during development. Increasing during development was the percentage of LPO units which displayed alteration of spike rate in response to hyperosmotic injections (osmosensitive). LPO units responsive to severe pain-arousal stimulation at all ages tested were found. The developmental changes in LPO unit activity characteristics paralleled the morphological development of LPO neurons and the development of osmotically induced drinking behaviors.