An accurate diagnostic approach for urothelial carcinomas based on novel dual methylated DNA markers in small-volume urine.
An accurate diagnostic approach for urothelial carcinomas based on novel dual methylated DNA markers in small-volume urine.
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DOI：
10.1097/cm9.0000000000002783
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发表时间：
2024-01-20
影响因子：
6.1
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中科院分区：
文献类型：
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Diagnostic methods for urothelial carcinomas (UCs) are often invasive or have suboptimal accuracy. Methylation of exfoliated cell DNA or cell-free DNA in urine has shown great promise in the diagnosis of UCs. However, most current studies have focused on bladder cancer (BCa), and only a few high-plex methylated DNA panels based on large-volume urine have been reported to exhibit both high sensitivity and specificity.[1, 2] The purpose of this study was to identify universal biomarkers for BCa and upper tract urothelial carcinoma (UTUC) using a small volume of urine. We developed a dual-target diagnostic panel comprising the novel marker AL021918. 2 and the well-known BCa biomarker Vimentin (VIM). This panel can accurately detect UCs using only 1.8 mL of full-voided urine.
