RF heating of deep brain stimulation implants in open-bore vertical MRI systems: A simulation study with realistic device configurations
RF heating of deep brain stimulation implants in open-bore vertical MRI systems: A simulation study with realistic device configurations
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DOI：
10.1002/mrm.28049
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发表时间：
2020-06-01
影响因子：
3.3
通讯作者：
Kirsch, John
中科院分区：
文献类型：
--
作者：
Golestanirad, Laleh;Kazemivalipour, Ehsan;Kirsch, John
目的：植入脑深部电刺激（DBS）植入物的患者从MRI中获益很大，但是，由于与植入物射频致热相关的安全性危险，这些患者的MRI访问受到限制。迄今为止，所有关于医疗植入物射频致热的MRI研究均在水平闭孔系统中进行。垂直MRI扫描仪具有完全不同的电场和磁场分布，现在可在1.2T下使用，能够进行高分辨率结构和功能MRI。这项工作提出了第一个模拟研究的DBS植入物在高场垂直scanners.Methods的射频加热：我们进行了有限元电磁模拟计算特定的吸收率（SAR）在DBS导线的尖端在MRI在市售的1.2T垂直线圈相比，一个1.5T的水平扫描仪。隔离导线和完全植入系统均包括在内。结果：我们发现，与水平鸟笼线圈相比，隔离DBS导线尖端的SAR降低了10至30倍，而完全植入系统中垂直线圈尖端的SAR降低了19倍。结论：如果在更大的患者队列中得到证实并通过实验验证，这一结果可以为过多的结构和功能MRI应用打开大门，以指导，解释，和先进的DBS疗法
Purpose: Patients with deep brain stimulation (DBS) implants benefit highly from MRI, however, access to MRI is restricted for these patients because of safety hazards associated with RF heating of the implant. To date, all MRI studies on RF heating of medical implants have been performed in horizontal closed-bore systems. Vertical MRI scanners have a fundamentally different distribution of electric and magnetic fields and are now available at 1.2T, capable of high-resolution structural and functional MRI. This work presents the first simulation study of RF heating of DBS implants in high-field vertical scanners.Methods: We performed finite element electromagnetic simulations to calculate specific absorption rate (SAR) at tips of DBS leads during MRI in a commercially available 1.2T vertical coil compared to a 1.5T horizontal scanner. Both isolated leads and fully implanted systems were included.Results: We found 10- to 30-fold reduction in SAR implication at tips of isolated DBS leads, and up to 19-fold SAR reduction at tips of leads in fully implanted systems in vertical coils compared to horizontal birdcage coils.Conclusions: If confirmed in larger patient cohorts and verified experimentally, this result can open the door to plethora of structural and functional MRI applications to guide, interpret, and advance DBS therapy.