A CONTROLLED TRIAL OF STIMULANT MEDICATION IN CHILDREN WITH THE FRAGILE-X SYNDROME
A CONTROLLED TRIAL OF STIMULANT MEDICATION IN CHILDREN WITH THE FRAGILE-X SYNDROME
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DOI：
10.1002/ajmg.1320300138
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发表时间：
1988-05-01
期刊：
影响因子：
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通讯作者：
WITTENBERGER, MD
中科院分区：
文献类型：
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作者：
HAGERMAN, RJ;MURPHY, MA;WITTENBERGER, MD
注意力缺陷和多动症经常是fra（X）男孩的主要问题。本研究评价了两种兴奋剂哌醋甲酯和苯丙胺与安慰剂相比对15名患有FRA（X）综合征的儿童（13名男性，2名女性）的有效性。采用双盲交叉设计，结果测量包括家长和教师行为检查表、对照观察期、连续执行任务和动作测量仪测量运动。当儿童仅接受哌醋甲酯治疗时，根据教师检查表，社会化技能和注意力持续时间有所改善。10名儿童在临床上被认为是应答者，研究完成后继续治疗。
Attentional deficits and hyperactivity frequently are major problems for fra (X) boys. This study evaluated the effectiveness of 2 stimulant medications, methylphenidate and dextroamphetamine compared to placebo in 15 children (13 males, 2 females) with the fra (X) syndrome. A double‐blind crossover design was used with outcome measures which included parent and teacher behavior checklists, a controlled observation period, continuous performance tasks and an actometer measure of movement. When the children were treated with methylphenidate only, improvement was seen in socialization skills and attention span according to teacher checklists. Ten children were clinically considered responders and treatment was continued after the study was completed.