THE SURVIVAL OF AEROBIC AND ANOXIC HUMAN GLIOMA AND MELANOMA-CELLS AFTER IRRADIATION AT ULTRAHIGH AND CLINICAL DOSE-RATES
THE SURVIVAL OF AEROBIC AND ANOXIC HUMAN GLIOMA AND MELANOMA-CELLS AFTER IRRADIATION AT ULTRAHIGH AND CLINICAL DOSE-RATES
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DOI：
10.2307/3578571
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发表时间：
1994-10-01
影响因子：
3.4
通讯作者：
RAAPHORST, GP
中科院分区：
文献类型：
--
作者：
CYGLER, J;KLASSEN, NV;RAAPHORST, GP
这项体外研究是为了确定高剂量率是否可以改善人类肿瘤的辐射反应。两个细胞系，人胶质瘤（U-87 MG），这是放射抗性，和人黑色素瘤（HT-144），这是放射敏感性，在有氧和缺氧条件下照射，以确定它们的氧增强比是否被修改的剂量率。事实上，发现生存曲线以及氧增强率与剂量率无关。对平台期照射的胶质瘤细胞氧增比为2.8（+/-0.3）。对于处于平台期的黑色素瘤细胞，氧增强比为2.7（+/-0.4），并且在指数期为2.8（+/-0.3）。这些结果表明，在治疗这些肿瘤时，使用高剂量率而不是常规剂量率没有优势。
This in vitro study was undertaken to determine if ultrahigh dose rates could improve the radiation response of human tumors. Two cell lines, human glioma (U-87 MG), which is radioresistant, and human melanoma (HT-144), which is radiosensitive, were irradiated at ultrahigh and high dose rates under aerobic and anoxic conditions to determine if their oxygen enhancement ratios are modified by dose rate. In fact, the survival curves, and hence the oxygen enhancement ratios, were found to be independent of the dose rate. The oxygen enhancement ratio for glioma cells irradiated in plateau phase was 2.8 (+/-0.3). The oxygen enhancement ratio was 2.7 (+/-0.4) for melanoma cells in plateau phase and 2.8 (+/-0.3) in exponential phase. These results indicate that there is no advantage in treating these tumors using ultrahigh dose rates instead of conventional dose rates.