Microstructure of frontoparietal connections predicts individual resistance to sleep deprivation
Microstructure of frontoparietal connections predicts individual resistance to sleep deprivation
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DOI：
10.1016/j.neuroimage.2014.11.035
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发表时间：
2015-02-01
期刊：
影响因子：
5.7
通讯作者：
Killgore, William D. S.
中科院分区：
文献类型：
--
作者：
Cui, Jiaolong;Tkachenko, Olga;Killgore, William D. S.
睡眠不足（SD）会降低认知功能，但越来越多的证据表明，这种影响的脆弱性存在很大的个体差异。一些证据表明，在工作记忆（WM）任务期间激活的额顶叶注意力系统的反应能力的基线差异可能与睡眠剥夺期间保持警惕的能力有关。然而，该网络背后的神经回路实际上仍未被探索。在本研究中，我们采用扩散张量成像 (DTI) 来研究连接额叶和顶叶区域的轴突通路（即上纵束 (SLF)）的微观结构与个体对 SD 的抵抗力之间的关联。 30 名年龄 20-43 岁的健康参与者（15 名男性）在 28 小时的 SD 期间之前在休息清醒状态下接受了功能磁共振成像 (fMRI) 和扩散张量成像 (DTI)。 Sternberg WM 任务期间与任务相关的额顶叶 fMRI 激活簇被定位并用作概率纤维束成像的种子区域。在 SLF 中测量了 DTI 指标，包括分数各向异性、平均扩散率、轴向和径向扩散率。精神运动警惕性测试（PVT）用于评估对 SD 的抵抗力。我们发现左顶下小叶（IPL）和背外侧前额叶皮层（DLPFC）的激活与阻力呈正相关。包含连接 IPL 和 DLPFC 的初级轴突的左侧 SLF 的较高分数各向异性也与更好的抵抗力相关。这些发现表明，对 SD 的抵抗力的个体差异与额顶叶注意力系统的功能反应性和轴突互连的微观结构特性有关。 (C) 2014 Elsevier Inc. 保留所有权利。
Sleep deprivation (SD) can degrade cognitive functioning, but growing evidence suggests that there are large individual differences in the vulnerability to this effect. Some evidence suggests that baseline differences in the responsiveness of a fronto-parietal attention system that is activated during working memory (WM) tasks may be associated with the ability to sustain vigilance during sleep deprivation. However, the neurocircuitry underlying this network remains virtually unexplored. In this study, we employed diffusion tensor imaging (DTI) to investigate the association between the microstructure of the axonal pathway connecting the frontal and parietal regions-i.e., the superior longitudinal fasciculus (SLF)-and individual resistance to SD. Thirty healthy participants (15 males) aged 20-43 years underwent functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) at rested wakefulness prior to a 28-hour period of SD. Task-related fronto-parietal fMRI activation clusters during a Sternberg WM Task were localized and used as seed regions for probabilistic fiber tractography. DTI metrics, including fractional anisotropy, mean diffusivity, axial and radial diffusivity were measured in the SLF. The psychomotor vigilance test (PVT) was used to evaluate resistance to SD. We found that activation in the left inferior parietal lobule (IPL) and dorsolateral prefrontal cortex (DLPFC) positively correlated with resistance. Higher fractional anisotropy of the left SLF comprising the primary axons connecting IPL and DLPFC was also associated with better resistance. These findings suggest that individual differences in resistance to SD are associated with the functional responsiveness of a fronto-parietal attention system and the microstructural properties of the axonal interconnections. (C) 2014 Elsevier Inc. All rights reserved.