ASSOCIATION OF AN INVERSION OF CHROMOSOME-16 WITH ABNORMAL MARROW EOSINOPHILS IN ACUTE MYELOMONOCYTIC LEUKEMIA - A UNIQUE CYTOGENETIC CLINICOPATHOLOGICAL ASSOCIATION
ASSOCIATION OF AN INVERSION OF CHROMOSOME-16 WITH ABNORMAL MARROW EOSINOPHILS IN ACUTE MYELOMONOCYTIC LEUKEMIA - A UNIQUE CYTOGENETIC CLINICOPATHOLOGICAL ASSOCIATION
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DOI：
10.1056/nejm198309153091103
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
ROWLEY, JD
中科院分区：
文献类型：
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作者：
LEBEAU, MM;LARSON, RA;ROWLEY, JD
我们在308例新诊断的急性非淋巴细胞白血病患者中发现了18例16号染色体inv(16)(P13q22)倒置的患者。这18例患者均为急性髓-单核细胞白血病(M4亚型)和嗜酸性粒细胞，其形态、细胞化学染色和超微结构明显异常。这些嗜酸性粒细胞占有核骨髓细胞的1%到33%。在我们的研究中，每个急性粒细胞白血病和嗜酸性粒细胞异常的患者都有16号染色体的异常。这组M4患者对旨在诱导缓解的强化治疗有良好的反应；17名接受治疗的患者中有13人进入完全缓解，10人仍处于首次缓解状态。因此，16号染色体倒位的患者似乎代表了一种独特的细胞遗传学-临床病理亚型的急性非淋巴细胞白血病，预后良好。《英国医学杂志》1983；309：630-6。
We identified 18 patients with an inversion of chromosome 16, inv(16)(p13q22), among 308 patients with newly diagnosed acute nonlymphocytic leukemia. Each of these 18 patients had acute myelomonocytic leukemia (M4 subtype) and eosinophils with distinctly abnormal morphology, cytochemical staining, and ultrastructure. These eosinophils constituted from 1 to 33 per cent of the nucleated marrow cells. In our series, every patient with acute myelomonocytic leukemia and abnormal eosinophils also had an abnormal chromosome 16. This subgroup of M4 patients had a good response to intensive therapy designed to induce remission; 13 of 17 treated patients entered a complete remission, and 10 remain in first remission. Thus, patients with an inversion of chromosome 16 appear to represent a unique cytogenetic–clinicopathological subtype of acute nonlymphocytic leukemia with a favorable prognosis. (N Engl J Med 1983; 309:630–6.)