Distribution of HLA antigens and haplotypes in the Buryat population of Siberia.
Distribution of HLA antigens and haplotypes in the Buryat population of Siberia.
复制标题
西伯利亚布里亚特人群中 HLA 抗原和单倍型的分布。
DOI：
10.1111/j.1399-0039.1995.tb02424.x
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
T. Akaza
中科院分区：
文献类型：
--
作者：
K. Tokunaga;E. W. Sideltseva;H. Tanaka;C. Uchikawa;M. Nieda;V. V. Sideltsev;E. Zhuravleva;T. Imanishi;K. Itoh;T. Akaza
研究了居住在西伯利亚的一个名叫布里亚特的蒙古族人群中人类白细胞抗原A、B、C、DR和DQ的多态性。从141名无血缘关系的布里亚特健康成人的人群数据中计算出人类白细胞抗原基因和单倍型频率。I类抗原A2、A24、A1、B61、CW10和CW6的基因频率估计在10%以上。对于II类，DR4、DR7、DR13、DQ7和DQ1抗原占优势。根据人类白细胞抗原基因频率构建系统发育树，将布里亚特人与东北亚地区的蒙古族群体聚为一类。在对人类白细胞抗原-A、C、B、DR和DQ五个基因座的单倍型频率分析中，有7种单倍型出现的频率超过2%。到目前为止，在其他人类群体中也描述了七种常见单倍型中的五种。其中一些单倍型已在欧洲种群中被描述，而另一些单倍型与东北亚蒙古人种和美洲印第安人共享。在对I类(HLA-A、C、B)三个基因座单倍型的分析中也发现了类似的情况。这些观察表明了这个布里亚特种群独特的遗传背景。
Polymorphisms of HLA-A, B, C, DR, and DQ antigens were investigated in a Mongoloid population named Buryat living in Siberia. HLA gene and haplotype frequencies were calculated from the population data obtained from 141 unrelated healthy Buryat adults. Gene frequencies of class I antigens A2, A24, A1, B61, Cw10, and Cw6 were estimated to be more than 10%. For class II, DR4, DR7, DR13, DQ7, and DQ1 antigens were predominant. A phylogenetic tree was constructed based on HLA gene frequencies, and the Buryat population was clustered with the Mongoloid groups in Northeast Asia. In the analysis of HLA-A, C, B, DR, and DQ five-locus haplotype frequencies, seven kinds of haplotypes were calculated to occur at frequencies of more than 2%. Five of the seven common haplotypes have also been described in the other human populations thus far. Some of the haplotypes have been described in European populations, while the others were shared with Northeast Asian Mongoloids as well as Amerindians. Similar situation was also found in the analysis of class I (HLA-A, C, B) three locus haplotypes. These observations suggest the unique genetic background of this Buryat population.