Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivo
Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivo
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DOI：
10.1038/ni832
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发表时间：
2002-09-01
影响因子：
30.5
通讯作者：
Seder, RA
中科院分区：
文献类型：
--
作者：
Wu, CY;Kirman, JR;Seder, RA
我们在这里研究了不同群体的T辅助1型（THI）-谱系细胞在体内的长期维持，发现效应THI细胞，由它们分泌的干扰素-γ（IFN-γ）定义，是短暂的，不能有效地发展成长期记忆THI细胞。相比之下，在初级抗原刺激后不分泌IFN-γ的活化的TH-谱系细胞群体在体内持续数月，并在随后的刺激后产生分泌IFN-γ的能力。这些数据表明，一个线性分化途径，定义为从IFN-γ-生产到静息记忆细胞的过渡，是相对有限的，在体内，并支持THI记忆分化的修订模型。
We studied here the long-term maintenance of distinct populations of T helper type 1 (THI)-lineage cells in vivo and found that effector THI cells, defined by their secretion of interferon-gamma (IFN-gamma), are short-lived and do not efficiently develop into long-term memory THI cells. In contrast, a population of activated THI-lineage cells that did not secrete IFN-gamma after primary antigenic stimulation persisted for several months in vivo and developed the capacity to secrete IFN-gamma upon subsequent stimulation. These data suggest that a linear differentiation pathway, as defined by the transition from IFN-gamma-producing to resting memory cells, is relatively limited in vivo and support a revised model for THI memory differentiation.