Cerebellar involvement in timing accuracy of rhythmic finger movements in essential tremor
Cerebellar involvement in timing accuracy of rhythmic finger movements in essential tremor
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DOI：
10.1111/j.1460-9568.2009.06984.x
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发表时间：
2009-11-01
影响因子：
3.4
通讯作者：
Abbruzzese, Giovanni
中科院分区：
文献类型：
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作者：
Avanzino, Laura;Bove, Marco;Abbruzzese, Giovanni
小脑参与特发性震颤 (ET) 的产生，并且 ET 患者的小脑计时功能发生改变，表现出节律性手部运动的变异性增加。我们使用传感器设计的手套，评估了 15 名 ET 患者和 11 名年龄和性别匹配的正常受试者在重复手指敲击动作时的运动行为。此外，我们还研究了在 ET 患者中，对小脑外侧进行抑制性重复经颅磁刺激 (1 Hz-rTMS) 是否能够改变计时特性和运动行为。与正常受试者相比，ET 患者的触摸持续时间 (TD) 更长，敲击间隔 (ITI) 更短。 ET 患者运动的时间变异性（ITI 变异系数）增加。临床评定量表或震颤测量值均与 ET 组的任何运动表现参数无关。通过降低 TD 值并使 ITI 值正常化，对同侧外侧小脑进行 1 Hz-rTMS 会暂时影响 ET 患者的表现。 1 Hz-rTMS后，ITI变异系数恢复至与正常受试者相似的值。我们假设增加 TD 的策略（可能是为了更好地感知运动而采用的）可以影响 ITI 及其变异性。结果支持这样的观点，即小脑在有节奏的手指运动的运动策略的选择中起着核心作用，特别是在运动的时间组织方面。
The cerebellum is involved in the generation of essential tremor (ET) and cerebellar timing function is altered in patients with ET showing an increased variability of rhythmic hand movements. Using a sensor-engineered glove, we evaluated motor behaviour during repetitive finger tapping movements in 15 patients with ET and in 11 age- and gender-matched normal subjects. In addition, we investigated whether, in patients with ET, an inhibitory repetitive transcranial magnetic stimulation (1 Hz-rTMS) over lateral cerebellum was able to change timing properties and motor behaviour. Patients with ET showed a longer touch duration (TD) and a lower inter tapping interval (ITI) than normal subjects. The temporal variability of the movement (coefficient of variation of ITI) was increased in patients with ET. Neither clinical rating scale or tremor measurements correlated with any parameter of motor performance in the ET group. 1 Hz-rTMS over ipsilateral lateral cerebellum transiently affected the performance of patients with ET, by reducing TD values and normalizing ITI values. After 1 Hz-rTMS, the coefficient of variation of ITI was restored to values similar to those of normal subjects. We postulate that the strategy to increase TD, probably adopted to allow a better perception of movement, can affect ITI and its variability. The results support the idea that the cerebellum plays a central role in the selection of motor strategy of rhythmic finger movements, particularly in terms of temporal organization of movement.