Endogenous α‐calcitonin gene‐related peptide mitigates liver fibrosis in chronic hepatitis induced by repeated administration of concanavalin A
Endogenous α‐calcitonin gene‐related peptide mitigates liver fibrosis in chronic hepatitis induced by repeated administration of concanavalin A
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DOI：
10.1111/j.1478-3231.2008.01841.x
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发表时间：
2009-05
影响因子：
6.7
通讯作者：
Akiko Kamiyoshi;T. Sakurai;Yuka Ichikawa-Shindo;Nobuyoshi Iinuma;Hisaka Kawate;T. Yoshizawa;T. Koyama;S. Muto;T. Shindo
中科院分区：
文献类型：
--
作者：
Akiko Kamiyoshi;T. Sakurai;Yuka Ichikawa-Shindo;Nobuyoshi Iinuma;Hisaka Kawate;T. Yoshizawa;T. Koyama;S. Muto;T. Shindo
背景资料：α-降钙素基因相关肽（αCGRP）是一种由37个氨基酸组成的多效性肽，我们先前已证明其在伴刀豆球蛋白A（Con A）诱导的急性肝炎中发挥保肝作用。在本研究中，我们使用αCGRP−/−小鼠进一步研究内源性αCGRP在Con A诱导的慢性肝炎中的抗纤维化和肝保护作用。
Background: α‐Calcitonin gene‐related peptide (αCGRP) is a 37‐amino acid pleiotropic peptide that we previously showed to exert a hepatoprotective effect during concanavalin A (Con A)‐induced acute hepatitis. In the present study, we used αCGRP−/− mice to further investigate the antifibrogenic and hepatoprotective effects of endogenous αCGRP in Con A‐induced chronic hepatitis.