Apoptosis of mesenchymal cells during the pseudoglandular stage of lung development affects branching morphogenesis.
Apoptosis of mesenchymal cells during the pseudoglandular stage of lung development affects branching morphogenesis.
复制标题
肺发育假腺体阶段间充质细胞的凋亡影响分支形态发生。
DOI：
10.1080/01902140802271842
复制
发表时间：
2008
影响因子：
1.7
通讯作者：
Roman,Jesse
中科院分区：
文献类型：
--
作者：
Wongtrakool,Cherry;Roman,Jesse
细胞凋亡是包括四肢、肾脏和心脏在内的多个器官系统发育的重要过程。在发育中的小鼠肺中，作者发现，在肺发育的假腺期比在囊状期细胞凋亡更占主导地位，93%的凋亡结构位于间充质中。在氯化锌和金精三羧酸（2种核酸内切酶功能阻断剂）存在下培养的小鼠肺外植体显示分支减少。这些观察结果表明，细胞凋亡占主导地位的间充质细胞在肺发育的假腺阶段，并可能是重要的肺分支形态发生的正常进展。
Apoptosis has been implicated as an important process in the development of several organ systems, including limbs, kidneys, and the heart. In developing murine lungs, the authors found that apoptosis was more predominant during the pseudoglandular stage of lung development than during the saccular stage, with 93% of the apoptotic structures in the mesenchyme. Murine lung explants cultured in the presence of zinc chloride and aurintricarboxylic acid, 2 blockers of endonuclease function, showed decreased branching. These observations suggest that apoptosis predominates in mesenchymal cells during the pseudoglandular stage of lung development, and may be important for normal progression of lung branching morphogenesis.