Risk factors associated with postoperative persistent hypertension in patients with primary aldosteronism.
Risk factors associated with postoperative persistent hypertension in patients with primary aldosteronism.
复制标题
原发性醛固酮增多症患者术后持续性高血压的危险因素。
DOI：
10.5555/uri:pii:003960609290299f
复制
发表时间：
1992
期刊：
影响因子：
3.8
通讯作者：
Yoshihide Fujimoto
中科院分区：
文献类型：
--
作者：
Takao Obara;Y. Ito;Takahiro Okamoto;Y. Kanaji;Tomoyuki Yamashita;Motohiko Aiba;Yoshihide Fujimoto
背景
对63例原发性醛固酮增多症患者行单侧肾上腺切除术。在平均4.1年的随访时间内，没有患者出现醛固酮增多症复发。然而，24例患者（38%）有持续性高血压。本研究的目的是确定术后持续性高血压的因素。
方法
采用逐步多变量logistic回归分析评估临床病理变量的联合预测作用。
结果
年龄、性别、病理结果是术后持续性高血压的最佳预测因素。对于50岁或以上的患者，与40岁以下的患者相比，持续高血压的几率为10.6：1。男性患者似乎比女性患者患高血压的机会更大;比值比为5.9：1。多发性腺瘤或腺瘤伴大结节患者发生持续性高血压的频率高于单发性腺瘤患者;比值比为8.1。
结论
这项研究表明，早期手术干预，在年轻的结果在一个更有利的结果原发性醛固酮增多症患者。肾上腺切除术后出现大结节伴腺瘤是持续性高血压的谨慎预测因素。
BACKGROUND
Unilateral adrenalectomy was performed in 63 patients with primary aldosteronism. During a mean follow-up time of 4.1 years, none of the patients showed recurrence of hyperaldosteronism. However, 24 patients (38%) had persistent hypertension. The purpose of this study was to determine factors responsible for postoperative persistent hypertension.
METHODS
A stepwise multivariate logistic regression analysis was performed to assess the combined predictive effects of the clinicopathologic variables.
RESULTS
Age, sex, and pathologic findings were the best predictive factors of postoperative persistent hypertension. For a patient aged 50 years or more, the odds of persisting hypertension are 10.6:1, compared with those of a patient under 40 years of age. A male patient appears to have a greater chance of hypertension than a female patient; the odds ratio is 5.9:1. Persistent hypertension develops in patients with multiple adenomas or with an adenoma associated with macronodules more frequently than in those patients with a solitary adenoma; the odds ratio is 8.1.
CONCLUSIONS
This study suggests that early surgical intervention at a younger age results in a more favorable outcome for patients with primary aldosteronism. The presence of macronodules in association with an adenoma is a cautious predictor of persistent hypertension after adrenalectomy.
原发性醛固酮增多症：诊断和治疗概念的改变。
影响因子：
3
作者：
LimJr,RC;Nakayama,DK;Biglieri,EG;Schambelan,M;Hunt,TK
通讯作者：
Hunt,TK