Maternal high-fat hypercaloric diet during pregnancy results in persistent metabolic and respiratory abnormalities in offspring.
Maternal high-fat hypercaloric diet during pregnancy results in persistent metabolic and respiratory abnormalities in offspring.
复制标题
DOI：
10.1038/pr.2015.226
复制
发表时间：
2016-02
影响因子：
3.6
通讯作者：
Piedimonte G
中科院分区：
文献类型：
--
作者：
Griffiths PS;Walton C;Samsell L;Perez MK;Piedimonte G
我们在以前的一项以人群为基础的研究中发现，儿童哮喘与早期脂质和葡萄糖代谢异常之间存在显著相关性。这项研究的具体目的是确定母亲在怀孕期间的营养是否会影响后代的出生后代谢和呼吸结果。在妊娠第1天，将母鼠从标准食物转换为高脂肪高热量饮食或对照饮食。对妊娠期和哺乳期饲喂研究饲料的母鼠的新生和断奶后代以及与母鼠保持相同饲料的成年后代进行终末实验。从高脂肪高热量饮食（HFD）母鼠出生的幼崽在整个发育过程中持续出现代谢异常。HFD母鼠新生儿肺组织的细胞因子表达分析显示了强烈的促炎模式。在HFD母鼠的断奶仔猪的肺中，神经营养因子和受体的基因表达上调，这与基线时较高的呼吸系统阻力和较低的顺应性以及对雾化乙酰甲胆碱的高反应性有关。此外，HFD母鼠生下的幼崽在呼吸道合胞病毒（RSV）感染后容易患上更严重的疾病。母亲在怀孕期间的营养是后代气道炎症和高反应性的关键决定因素，也增加了独立于孕前营养的毛细支气管炎的风险。
We have shown in a previous population-based study significant correlation between childhood asthma and early abnormalities of lipid and glucose metabolism. This study's specific aim was to determine whether maternal nutrition in pregnancy affects postnatal metabolic and respiratory outcomes in the offspring. On gestation day 1, dams were switched from standard chow to either high-fat hypercaloric diet or control diet. Terminal experiments were performed on newborn and weanling offspring of dams fed the study diet during gestation and lactation, and on adult offspring maintained on the same diet as their mother. Pups born from high-fat hypercaloric diet (HFD) dams developed metabolic abnormalities persistent throughout development. Cytokine expression analysis of lung tissues from newborns born to HFD dams revealed a strong proinflammatory pattern. Gene expression of neurotrophic factors and receptors was upregulated in lungs of weanlings born to HFD dams, and this was associated to higher respiratory system resistance and lower compliance at baseline, as well as hyperreactivity to aerosolized methacholine. Furthermore, HFD dams delivered pups prone to develop more severe disease after respiratory syncytial virus (RSV) infection. Maternal nutrition in pregnancy is a critical determinant of airway inflammation and hyperreactivity in offspring and also increases risk for bronchiolitis independent from prepregnancy nutrition.