Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum
Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum
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DOI：
10.1126/science.282.5391.1126
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发表时间：
1998-11-06
期刊：
影响因子：
56.9
通讯作者：
Hoffman, SL
中科院分区：
文献类型：
--
作者：
Gardner, MJ;Tettelin, H;Hoffman, SL
对恶性疟原虫2号染色体进行了测序，该序列包含947,103个碱基对，编码210个预测基因。与酿酒酵母基因组相比，2号染色体的基因密度更低，内含子更频繁，蛋白质明显富含在非小叶结构域中。鉴定了一个表面蛋白家族，即Rifins，它可能在抗原变异中发挥作用。对2号染色体的完整测序表明，对富含A+T的恶性疟原虫基因组进行测序在技术上是可行的。
Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A + T-rich P. falciparum genome is technically feasible.