Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men
Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men
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DOI：
10.3945/ajcn.2008.26761
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发表时间：
2009-07-01
影响因子：
7.1
通讯作者：
Sekikawa, Akira
中科院分区：
文献类型：
--
作者：
Motoyama, Kenneth R.;Curb, J. David;Sekikawa, Akira
背景：不同人群血清多不饱和脂肪酸（PUFAs）与血脂的关系尚不清楚。目的：我们的目的是检查血清n-6 （ω -6）或n-3 (ω -3) PUFAs与甘油三酯或hdl -胆固醇浓度的关系，研究对象为261名40岁至49岁的白人、285名日本人和212名日裔美国人。在原始样本（n = 926）中，排除了服用降脂药物或患有糖尿病的人（n = 168）。采用毛细管气液色谱法分析血清脂肪酸。采用多元回归模型作为各PUFA成分组的函数。结果：在调整了年龄、体重指数、吸烟年数和乙醇消耗量后，血清n-6 PUFAs与甘油三酯呈显著负相关[分别在白人、日本人和日裔美国人中β = -0.39 （P < 0.001）、-0.38 （P < 0.001）和-0.33 (P < 0.001)]。海洋n-3 PUFAs与甘油三酯在人群中呈显著负相关[在白人、日本人和日裔美国人中分别为-0.15 （P < 0.001）、-0.22 （P < 0.001）和-0.13 (P < 0.001)]。白种人（β = 4.49, P < 0.001）和日本人（β = 3.73, P < 0.01）的n-6 PUFAs与高密度脂蛋白胆固醇呈显著正相关。海洋n-3 PUFAs与日本人高密度脂蛋白胆固醇呈极显著正相关（β = 2.15, P < 0.05），二十碳五烯酸与白人高密度脂蛋白胆固醇呈极显著正相关（β = 2.68, P < 0.01）。结论：人群中血清n-6和n-3 PUFAs与甘油三酯呈负相关。[J]中华临床医学杂志，2009;39(4):349 - 355。
Background: The association of serum polyunsaturated fatty acids (PUFAs) with lipids in different populations is not known.Objective: Our aim was to examine the association of serum n-6 (omega-6) or n-3 (omega-3) PUFAs with triglycerides or HDL-cholesterol concentrations in 261 white, 285 Japanese, and 212 Japanese American men aged 40 49 y.Design: We used a population-based cross-sectional study. Of the original sample (n = 926), those taking lipid-lowering medications or who had diabetes (n = 168) were excluded. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Multiple regression models as a function of tertile groups of each PUFA were used.Results: Serum n-6 PUFAs were significantly inversely associated with triglycerides across populations after adjustment for age, body mass index, pack-years of smoking, and ethanol consumption [beta = -0.39 (P < 0.001), -0.38 (P < 0.001), and -0.33 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. Marine n-3 PUFAs were significantly inversely associated with triglycerides across populations [beta = -0.15 (P < 0.001), -0.22 (P < 0.001), and -0.13 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. n-6 PUFAs were significantly positively associated with HDL cholesterol in whites (beta = 4.49, P < 0.001) and Japanese (beta = 3.73, P < 0.01). Marine n-3 PUFAs were significantly positively associated with HDL cholesterol in Japanese (beta = 2.15, P < 0.05), and eicosapentaenoic acid was significantly positively associated with HDL cholesterol in whites (beta = 2.68, P < 0.01).Conclusion: Serum n-6 and n-3 PUFAs are inversely associated with triglycerides across populations. Am J Clin Nutr 2009;90:49-55.