Sorting Out Presenilins in Alzheimer's Disease.
Sorting Out Presenilins in Alzheimer's Disease.
复制标题
筛选阿尔茨海默病中的早老素。
DOI：
10.1016/j.cell.2016.06.034
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发表时间：
2016
期刊：
影响因子：
64.5
通讯作者：
Yankner,BruceA
中科院分区：
文献类型：
--
作者：
Wolfe,MichaelS;Yankner,BruceA
Mutations in the presenilins that cause familial Alzheimer's disease alter the activity of these proteases to increase generation of an aggregation-prone isoform of the amyloid β-peptide (Aβ). How these mutations do so has been unclear. Sannerud et al. now show that regulation of subcellular localization plays a central role, advancing our understanding of the cell biology of Alzheimer's disease.
