Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.
Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.
复制标题
DOI：
10.1038/srep45050
复制
发表时间：
2017-03-23
影响因子：
4.6
通讯作者：
Yabe H
中科院分区：
文献类型：
--
作者：
Matsumoto J;Nakanishi H;Kunii Y;Sugiura Y;Yuki D;Wada A;Hino M;Niwa SI;Kondo T;Waki M;Hayasaka T;Masaki N;Akatsu H;Hashizume Y;Yamamoto S;Sato S;Sasaki T;Setou M;Yabe H
精神分裂症的病因包括磷脂异常。磷脂是大脑功能所必需的生物活性物质。为了分析精神分裂症患者脑组织中存在的磷脂的数量和类型的差异，我们利用LC-ESI/MS/MS和成像质谱仪(IMS)对多个脑组织样本中的磷脂进行了全局分析。在LC-ESI/MS/MS实验中，我们发现精神分裂症患者大脑前额叶皮质(PFC)中16：0/20：4-磷脂酰肌醇(PI)含量显著降低，其中灰质中16：0/20：4-PI含量降低最为显著。以前研究精神分裂症PI病理的报道没有发现sn-1和sn-2脂肪酰链的差异。这项研究首次明确了精神分裂症患者大脑中PI的脂肪酸组成。PI特征脂肪酸组成的改变也可能影响神经元功能，并可能在精神分裂症的病因中发挥作用。虽然还需要进一步的研究来了解前额叶皮质中降低的16：0/20：4-PI水平在精神分裂症病因中的作用，但我们的结果为临床治疗精神分裂症提供了一种新的治疗方法的开发。
The etiology of schizophrenia includes phospholipid abnormalities. Phospholipids are bioactive substances essential for brain function. To analyze differences in the quantity and types of phospholipids present in the brain tissue of patients with schizophrenia, we performed a global analysis of phospholipids in multiple brain samples using liquid chromatography electrospray ionization mass/mass spectrometry (LC-ESI/MS/MS) and imaging mass spectrometry (IMS). We found significantly decreased 16:0/20:4-phosphatidylinositol (PI) levels in the prefrontal cortex (PFC) in the brains from patients with schizophrenia in the LC-ESI/MS/MS, and that the 16:0/20:4-PI in grey matter was most prominently diminished according to the IMS experiments. Previous reports investigating PI pathology of schizophrenia did not identify differences in the sn-1 and sn-2 fatty acyl chains. This study is the first to clear the fatty acid composition of PI in brains from patients with schizophrenia. Alteration in the characteristic fatty acid composition of PI may also affect neuronal function, and could play a role in the etiology of schizophrenia. Although further studies are necessary to understand the role of reduced 16:0/20:4-PI levels within the prefrontal cortex in the etiology of schizophrenia, our results provide insight into the development of a novel therapy for the clinical treatment of schizophrenia.