High β-carotene and β-cryptoxanthin are associated with low pulse wave velocity
High β-carotene and β-cryptoxanthin are associated with low pulse wave velocity
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DOI：
10.1016/j.atherosclerosis.2005.04.006
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发表时间：
2006-02-01
期刊：
影响因子：
5.3
通讯作者：
Aoki, N
中科院分区：
文献类型：
--
作者：
Nakamura, M;Sugiura, M;Aoki, N
抗氧化剂在预防糖尿病血管并发症方面有潜在的好处，因为在这种情况下，氧化应激会增强，并在血管疾病中发挥重要作用。本研究旨在研究根据血糖状态分层的高血清类胡萝卜素浓度是否会降低臂踝脉搏波速度(BaPWV)。共有297名年龄在30岁到70岁之间的男性和579名女性接受了横截面分析。在空腹血糖正常的情况下，β-胡萝卜素的最高三分位数(1386 cm/S)低于最低三分位数(1432 cm/S)，P-隐黄素最高三分位数(1382 cm/S)低于中三分位数(1424 cm/S)。然而，在一组既有空腹血糖受损又有糖尿病的受试者中，观察到了类似的反向关联，但没有统计学意义。类胡萝卜素含量最高的三分位数与BaPWV升高的风险较低(>；=1680 cm/S)。年龄、性别和血糖水平调整后的优势比为0.35(95%可信区间0.20~0.60)，β-胡萝卜素为0.45(0.27~0.77)。多变量调整没有改变结果。总而言之，BaPWV与β-胡萝卜素和β-隐黄素呈负相关，与血糖状态无关。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Antioxidants are potentially beneficial in preventing vascular complications in diabetes because oxidative stress would be enhanced in such a condition and play an important role in vascular disorders. This study aimed to investigate whether brachial-ankle pulse wave velocity (baPWV) would be lower in the presence of high serum carotenoid concentrations stratified according to the glycemic state. A total of 297 men and 579 women between 30 and 70 years of age were analyzed cross-sectionally. Multivariate adjusted mean of baPWV in the highest tertile for P-carotene (1386 cm/s) was lower than that in the lowest tertile (1432 cm/s) and that in the highest tertile for P-cryptoxanthin (1382 cm/s) was lower than that in the middle tertile (1424 cm/s) in the case of normal fasting glucose. Similar inverse associations were observed in a group that included subjects with both impaired fasting glucose and diabetes, however, without statistical significance. The highest tertile of carotenoids was associated with a low risk for high baPWV (>= 1680 cm/s). Age, sex and glycemic state adjusted odds ratio was 0.35 (95% CI 0.20-0.60) for beta-carotene and 0.45 (0.27-0.77) for beta-cryptoxanthin. Multivariate adjustment did not alter the results. In conclusion, an inverse association of baPWV with beta-carotene and beta-cryptoxanthin was observed independently of the glycemic state. (c) 2005 Elsevier Ireland Ltd. All rights reserved.