New surface modification of titanium implant with phospho-amino acid
New surface modification of titanium implant with phospho-amino acid
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DOI：
10.4012/dmj.24.536
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发表时间：
2005-12-01
影响因子：
2.5
通讯作者：
Akagawa, Y
中科院分区：
文献类型：
--
作者：
Abe, Y;Hiasa, K;Akagawa, Y
本研究的目的是探索一种新型的磷酸化氨基酸钛种植体表面生化修饰技术。纯钛圆盘分别用10N盐酸和超纯水在室温下处理30min。然后用L-苏氨酸(Thr)或O-磷酸-L-苏氨酸(P-Thr)在37℃下对这些圆盘进行12小时的修饰。用X射线光电子能谱(XPS)对改性后的表面进行了化学分析。结果表明，在Thr修饰表面的宽扫描光谱中未检测到源于Thr的N is峰，而在P-Thr修饰表面的宽扫描光谱中检测到了来自P-Thr的N1s、P2s和P2p三个峰。此外，与表面反应的P-Thr的P2p峰显著向较低的结合能移动(p<；0.05)。根据本研究的结果，得出结论：经盐酸处理的钛表面上，P-苏氨酸以化学键合的方式存在。
The purpose of this study was to investigate a new biochemical surface modification technique for titanium implants using phospho-amino acid. Pure titanium disks were pretreated with 10 N HCl and ultrapure water at room temperature for 30 Minutes respectively. Then these disks were modified with either L-threonine (Thr) or O-phospho-L-threonine (P-Thr) at 37 degrees C for 12 hours. X-ray photoelectron spectroscopy (XPS) chemically analyzed the modified surfaces. It was revealed that the N Is peak which originated from Thr was not detected in the wide-scan spectrum of Thr-modified surface, whereas three peaks of N 1s, P 2s, and P 2p which originated from P-Thr were detected in the wide-scan spectrum of P-Thr-modified surface. Moreover, the P 2p peak of P-Thr which reacted with the surface significantly shifted to a lower binding energy (p < 0.05). Based on the results of this study, it was concluded that P-Thr chemically bonded to the titanium surface treated with HCl.