T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation.
T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation.
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t对健康和神经炎症中的ST2信号传导的核对细胞中心需求。
DOI：
10.1084/jem.20201234
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发表时间：
2021-02-01
期刊：
影响因子：
--
通讯作者：
Rudensky AY
中科院分区：
文献类型：
--
作者：
Hemmers S;Schizas M;Rudensky AY
ST2 expression was largely dispensable for T reg cell accumulation and maintenance in tissues at steady state. However, ST2 deficiency limited to T reg cells was important in limiting the size of IL-17A–producing γδT cells in a mouse model of neuroinflammation. ST2, the receptor for the alarmin IL-33, is expressed by a subset of regulatory T (T reg) cells residing in nonlymphoid tissues, and these cells can potently expand upon provision of exogenous IL-33. Whether the accumulation and residence of T reg cells in tissues requires their cell-intrinsic expression of and signaling by ST2, or whether indirect IL-33 signaling acting on other cells suffices, has been a matter of contention. Here, we report that ST2 expression on T reg cells is largely dispensable for their accumulation and residence in nonlymphoid organs, including the visceral adipose tissue (VAT), even though cell-intrinsic sensing of IL-33 promotes type 2 cytokine production by VAT-residing T reg cells. In addition, we uncovered a novel ST2-dependent role for T reg cells in limiting the size of IL-17A–producing γδT cells in the CNS in a mouse model of neuroinflammation, experimental autoimmune encephalomyelitis (EAE). Finally, ST2 deficiency limited to T reg cells led to disease exacerbation in EAE.
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影响因子：
32.4
作者：
Hou, Baidong;Reizis, Boris;DeFranco, Anthony L.
通讯作者：
DeFranco, Anthony L.
影响因子：
25
作者：
Dombrowski Y;O'Hagan T;Dittmer M;Penalva R;Mayoral SR;Bankhead P;Fleville S;Eleftheriadis G;Zhao C;Naughton M;Hassan R;Moffat J;Falconer J;Boyd A;Hamilton P;Allen IV;Kissenpfennig A;Moynagh PN;Evergren E;Perbal B;Williams AC;Ingram RJ;Chan JR;Franklin RJM;Fitzgerald DC
通讯作者：
Fitzgerald DC
影响因子：
32.4
作者：
Delacher, Michael;Imbusch, Charles D.;Feuerer, Markus
通讯作者：
Feuerer, Markus
影响因子：
30.5
作者：
通讯作者：
--
DOI：
10.1084/jem.20070318
发表时间：
2007-10-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hövelmeyer N;Wunderlich FT;Massoumi R;Jakobsen CG;Song J;Wörns MA;Merkwirth C;Kovalenko A;Aumailley M;Strand D;Brüning JC;Galle PR;Wallach D;Fässler R;Waisman A
通讯作者：
Waisman A