Breathing disorders during sleep and cognitive performance in an older community sample: The EVA study
Breathing disorders during sleep and cognitive performance in an older community sample: The EVA study
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DOI：
10.1111/j.1532-5415.1996.tb01397.x
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发表时间：
1996-11-01
影响因子：
6.3
通讯作者：
Alperovitch, A
中科院分区：
文献类型：
--
作者：
Dealberto, MJ;Pajot, N;Alperovitch, A
目的：为了确定认知能力差是否与睡眠呼吸暂停综合征、打鼾和睡眠呼吸停止相关的症状有关。设计：伊娃研究中基线收集的数据的横断面分析，这是一项为期4年的队列研究。从南特市的选民名册中共招募了1 389名年龄在60至70岁之间的人。测量方法：使用标准化问卷收集人口统计学特征和药物使用和烟草及酒精消费的数据。测量体重和身高。受试者完成了一份关于夜间睡眠特征、打鼾、睡眠期间呼吸停止和白天嗜睡的先前验证过的睡眠问卷。训练有素的心理学家进行了八项神经心理学测试：简易精神状态检查、连线测试、WAIS修订版数字符号替换测试、Benton视觉保留测试、节奏听觉连续加法任务、听觉言语学习测试、Raven递进测验和文字流畅性测试。抑郁症的发病率由流行病学研究中心的抑郁量表进行评估。主要结果：在这个较老的样本中，49.5%的受试者报告打鼾，10.8%的人报告睡眠期间呼吸停止。两种呼吸系统疾病均与男性和高体重指数显著相关。在男性中，打鼾的患病率在每天饮酒量超过40公吨的人中显着增加。睡眠期间呼吸停止与女性抑郁症状有关。Logistic回归模型调整了年龄、性别、教育水平、吸烟状况和饮酒量、抑郁症和药物治疗数量，发现打鼾和呼吸停止与低评分相关（小于或等于第10百分位数）在测试中需要视觉注意力的技能，线索制作测试OR=2.14，95%CI =1.24-3.69; OR=1.88，95%CI =1.04-3.39;数字符号替换检验OR=1.80，95%CI =1.09-2.99; OR=1.58，95%CI = 0.87 ~ 2.89。这些关系是显着的，只有当打鼾或呼吸停止与白天sleepy.Conclusions：这一横截面分析表明，在社区居住的个人60至70岁，打鼾和呼吸停止在睡眠期间与白天嗜睡的风险因素低认知性能的测试，需要视觉注意力技能。
OBJECTIVES: To determine whether poor cognitive performance was associated with symptoms related to the sleep apnea syndrome, snoring, and breathing stoppage during sleep.DESIGN: Cross-sectional analysis of data collected at baseline in the EVA Study, a 4-year cohort study.SETTING: The city of Nantes in western France.SAMPLE: A total of 1389 persons, aged 60 to 70 years, recruited from the electoral rolls of the city of Nantes.MEASUREMENTS: Demographic characteristics and data on drug use and tobacco and alcohol consumption were collected using a standardized questionnaire. Weight and height were measured. Individuals completed a previously validated sleep questionnaire about nocturnal sleep characteristics, snoring, breathing stoppage during sleep, and daytime sleepiness. Trained psychologists administered eight neuropsychological tests: The Mini-Mental State Examination, Trail Making Test, Digit Symbol Substitution Test of the WAIS-Revised, Benton Visual Retention Test, Paced Auditory Serial-Addition Task, Auditory Verbal Learning Test, Raven Progressive Matrices, and Word Fluency Test. Depressive symptomatology was assessed by the Center for Epidemiologic Studies-Depression scale.MAIN RESULTS: In this older sample, 49.5% of subjects reported snoring, and 10.8% reported breathing stoppage during sleep. Both respiratory disorders were associated significantly with male gender and high body mass index. In men, prevalence of snoring was increased significantly in those with alcohol consumption greater than 40 mt per day. Breathing stoppage during sleep was associated with depressive symptoms in women. Logistic regression models adjusted for age, gender, educational level, tobacco status and alcohol consumption, depressive symptomatology, and number of medications found that both snoring and breathing stoppage were associated with low scores (less than or equal to 10th percentile) in tests requiring visual attention skills, the Trail Making Test (OR=2.14, 95% CI=1.24-3.69 and OR=1.88, 95% CI=1.04-3.39, respectively), and the Digit Symbol Substitution Test (OR=1.80, 95% CI=1.09-2.99 and OR=1.58, 95% CI=.87-2.89, respectively). These relationships were significant only when either snoring or breathing stoppage was associated with daytime sleepiness.CONCLUSIONS: This cross-sectional analysis suggested that in community-dwelling individuals 60 to 70 years of age, snoring and breathing stoppage during sleep associated with daytime sleepiness were risk factors for low cognitive performance in tests requiring visual attention skills.