Life events stress and psychosocial factors in men with peptic ulcer disease. II. Relationships with serum pepsinogen concentrations and behavioral risk factors.
Life events stress and psychosocial factors in men with peptic ulcer disease. II. Relationships with serum pepsinogen concentrations and behavioral risk factors.
复制标题
患有消化性溃疡病的男性的生活事件压力和心理社会因素。
DOI：
10.1016/0016-5085(88)90419-2
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发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
Feldman,M
中科院分区：
文献类型：
--
作者：
Walker,P;Luther,J;Samloff,IM;Feldman,M
我们在一项对照研究中检查了男性消化性溃疡患者的心理障碍是否与其他潜在的溃疡“危险因素”（血清胃蛋白酶原浓度、吸烟、饮酒、阿司匹林或咖啡）有关。一般精神病理学、敌对、易怒和过敏的人格特征以及应对能力受损（低自我强度）均与溃疡患者的血清胃蛋白酶原浓度显著相关（p ≤ 0.005）。溃疡患者吸烟、饮酒和阿司匹林摄入量增加，但与精神病理学无关。抑郁症的变量，最好的区分溃疡患者从非溃疡控制;生活事件的负面看法，溃疡的亲属人数，血清胃蛋白酶原I浓度也有一个主要的，独特的判别值，而吸烟起着相对较小的作用独立于其他变量的检查。我们的研究支持这样的概念，即几个相互作用的因素（心理，行为和遗传/生理）可能参与消化性溃疡疾病。情绪压力可通过引起胃分泌过多而易患溃疡，表现为高胃蛋白酶原血症。
We examined in a controlled study whether psychologic disturbances in men with peptic ulcer disease were related to other potential ulcer “risk factors” (serum pepsinogen concentrations, cigarette smoking, and intake of alcohol, aspirin, or coffee). Psychopathology in general, personality features of hostility, irritability, and hypersensitivity, and impaired coping ability (low ego strength) each correlated significantly with serum pepsinogen concentration in ulcer patients (p ≤ 0.005). Cigarette smoking and intake of alcohol and aspirin were increased in ulcer patients but unrelated to psychopathology. Depression was the variable that best discriminated ulcer patients from nonulcer controls; a negative perception of life events, number of relatives with ulcer, and serum pepsinogen I concentration also had a major, unique discriminating value, whereas smoking played a relatively minor role independent of the other variables examined. Our study supports the concept that several interacting factors (psychologic, behavioral, and genetic/physiologic) are likely involved in peptic ulcer disease. Emotional stress may predispose to ulcers by producing gastric hypersecretion, as manifested by hyperpepsinogenemia.