The Mnx homeobox gene class defined by HB9, MNR2 and amphioxus AmphiMnx
The Mnx homeobox gene class defined by HB9, MNR2 and amphioxus AmphiMnx
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DOI：
10.1007/s004270000124
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发表时间：
2001-02-01
影响因子：
2.4
通讯作者：
Holland, PWH
中科院分区：
文献类型：
--
作者：
Ferrier, DEK;Brooke, NM;Holland, PWH
HB9同源盒基因已从几种脊椎动物中克隆，并与运动神经元分化有关。在鸡中，一个相关的基因MNR 2在这个过程中作用于HB9的上游。在这里，我们报告了这些基因的文昌鱼同源物，并表明它在基因复制产生HB9和MNR 2之前出现分歧。AmphiMnx RNA被检测到在两个不规则的点状条纹沿着发育的神经管，相当于“背室”运动神经元的分布，也在背内胚层和后中胚层。我们提出了一个新的同源异型盒类，Mnx，包括AmphiMnx，HB9，MNR 2和他们的果蝇和棘皮动物直系同源，我们建议脊椎动物HB9更名为Mnx1和MNR 2更名为Mnx2。
The HB9 homeobox gene has been cloned from several vertebrates and is implicated in motor neuron differentiation. In the chick, a related gene, MNR2, acts upstream of HB9 in this process. Here we report an amphioxus homologue of these genes and show that it diverged before the gene duplication yielding HB9 and MNR2. AmphiMnx RNA is detected in two irregular punctate stripes along the developing neural tube, comparable to the distribution of 'dorsal compartment' motor neurons, and also in dorsal endoderm and posterior mesoderm. We propose a new homeobox class, Mnx, to include AmphiMnx, HB9, MNR2 and their Drosophila and echinoderm orthologues; we suggest that vertebrate HB9 is renamed Mnx1 and MNR2 be renamed Mnx2.