2-Amino-7-phosphonoheptanoic acid depresses gamma-motoneurons and polysynaptic reflexes in the cat spinal cord.
2-Amino-7-phosphonoheptanoic acid depresses gamma-motoneurons and polysynaptic reflexes in the cat spinal cord.
复制标题
2-氨基-7-膦酰庚酸抑制猫脊髓中的 γ 运动神经元和多突触反射。
DOI：
10.1016/0014-2999(85)90015-9
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发表时间：
1985
影响因子：
5
通讯作者：
P. Polc
中科院分区：
文献类型：
--
作者：
P. Polc
研究了N-甲基-D-天冬氨酸(NMDA)受体选择性拮抗剂2-氨基-7-膦庚酸(APH)对非麻醉脊髓猫脊髓功能的影响。APH(10 mg/kg静脉注射)抑制γ运动神经元和节段性多突触腹根反射的自发活动，但不影响单突触腹根反射。APH可拮抗N-甲基-D-天冬氨酸诱导的多突触VRR的增强和γ运动神经元的激活。结果支持NMDA型受体参与运动神经元(包括γ-运动神经元)的多突触兴奋，从而参与脊髓运动功能的假说。
The effects of 2-amino-7-phosphonoheptanoic acid (APH), a selective antagonist of N-methyl-D-aspartate (NMDA) receptors, were studied on spinal cord functions in unanaesthetized spinal cats. APH (10 mg/kg i.v.) depressed spontaneous activity of γ-motoneurons and segmental polysynaptic ventral root reflexes (VRRs) without affecting monosynaptic VRRs. The NMDA-induced enhancement of polysynaptic VRRs and activation of γ-motoneurons were antagonized by APH. The results support the hypothesis that NMDA receptors are involved in the polysynaptic excitation of motoneurons, including γ-motoneurons, and thus participate in motor functions of the spinal cord.