The Purkinje cell; 2008 style.

The Purkinje cell; 2008 style.
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DOI:
10.1016/j.yjmcc.2008.08.001
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发表时间:
2008-11
影响因子:
5
通讯作者:
Boyden, Penelope A.
Boyden, Penelope A.
中科院分区:
医学2区
文献类型:
--
作者:
Dun, Wen;Boyden, Penelope A.

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心脏浦肯野纤维由于其独特的解剖位置、细胞结构和电生理特性,在心脏传导和心律失常发生中发挥着重要作用。浦肯野细胞的动作电位比它们的心室对应电位长,并显示两个水平的静息电位。浦肯野细胞提供心脏冲动向心室细胞的快速传播,并具有起搏器和触发活动,这与心室细胞不同。此外,一个独特的细胞内Ca2+释放协调最近被发现为正常的浦肯野细胞。然而,由于单个浦肯野细胞的分离是困难的,特别是在小动物中,使用浦肯野细胞的研究一直受到限制。本文通过总结目前对浦肯野细胞的认识,对浦肯野细胞和心室细胞在动作电位形态、离子通道功能和分子决定因素方面的比较进行了综述。
Cardiac Purkinje fibers, due to their unique anatomical location, cell structure and electrophysiologic characteristics, play an important role in cardiac conduction and arrhythmogenesis. Purkinje cell action potentials are longer than their ventricular counterpart, and display two levels of resting potential. Purkinje cells provide for rapid propagation of the cardiac impulse to ventricular cells and have pacemaker and triggered activity, which differs from ventricular cells. Additionally, a unique intracellular Ca2+ release coordination has been revealed recently for the normal Purkinje cell. However, since the isolation of single Purkinje cells is difficult, particularly in small animals, research using Purkinje cells has been restricted. This review concentrates on comparison of Purkinje and ventricular cells in the morphology of the action potential, ionic channel function and molecular determinants by summarizing our present day knowledge of Purkinje cells.
DOI: 10.1085/jgp.70.6.725
发表时间: 1977-12
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