Effect of acute and chronic ethanol treatment on rat brain phospholipid turnover.
Effect of acute and chronic ethanol treatment on rat brain phospholipid turnover.
复制标题
急性和慢性乙醇治疗对大鼠脑磷脂周转的影响。
DOI：
10.1016/0006-2952(80)90016-7
复制
发表时间：
1980
影响因子：
5.8
通讯作者：
Loh,HH
中科院分区：
文献类型：
--
作者：
Lee,NM;Friedman,HJ;Loh,HH
在体外研究了（1）急性剂量的乙醇，（2）对乙醇产生耐受后，（3）对乙醇的身体依赖性，和（4）从依赖中戒断后大鼠脑中的磷脂周转。结果发现，营业额的磷脂酰胆碱，磷脂酰肌醇/磷脂酰丝氨酸和磷脂酰乙醇胺的增加，在耐受性的动物和耐受性开发这些增加依赖性的动物。在戒断依赖的动物中，观察到微粒体组分中32 P标记的磷脂酰肌醇/磷脂酰丝氨酸的急剧减少。
Phospholipid turnover was studied in the rat brain after treatmentin vitrowith (1) an acute dose of ethanol, (2) after the development of tolerance to ethanol, (3) of physical dependence on ethanol, and (4) of withdrawal from dependence. It was found that the turnover of phosphatidylcholine, of phosphatidylinosotol/phosphatidylserine and of phosphatidylethanolamine was increased in tolerant animals and that tolerance developed to these increases in dependent animals. A drastic decrease in32P-labeled phosphatidylinositol/phosphatidylserine of microsomal fractions was observed in animals withdrawing from dependence.