Human galectin-8 isoforms and cancer
Human galectin-8 isoforms and cancer
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DOI：
10.1023/b:glyc.0000014086.38343.98
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发表时间：
2002-01-01
影响因子：
3
通讯作者：
Le Pennec, JP
中科院分区：
文献类型：
--
作者：
Bidon-Wagner, N;Le Pennec, JP
Galectins是一种动物凝集素，可以特异性地结合β-半乳糖苷。已经描述了13个Galectins。本综述重点介绍该家族的一个特定成员：Galectin-8。这种半乳凝素是八年前在前列腺癌细胞中发现的，在过去的几年里得到了广泛的研究。Galectin-8基因(LGALS8)通过交替剪接和存在三个不寻常的多聚腺苷信号来编码大量的mRNAs。这些mRNA编码六种不同的Galectin-8亚型：三种属于串联重复Galectin组(两个CRD由铰链多肽连接)，三种属于原型组(一种CRD)。各种研究表明Galectin-8在肿瘤组织和正常组织中广泛表达。Galectin-8的表达水平可能与结肠癌的恶性程度、肺鳞状细胞癌和神经内分泌肿瘤的分化程度有关。最近，Galectin-8在正常组织和肿瘤组织中表达水平的差异已被用作选择预防和治疗肺鳞癌的策略的指导。这些实验仍在研究中，但证明了Galectin-8研究的潜力，以增强我们对肿瘤转化过程的理解，并可能防止肿瘤转化。
Galectins are animal lectins that can specifically bind beta-galactosides. Thirteen galectins have already been described. This review focuses on a specific member of this family: galectin-8. This galectin was discovered in prostate cancer cells eight years ago and has been studied extensively in the last few years. The galectin-8 gene (LGALS8) encodes numerous mRNAs by alternate splicing and the presence of three unusual polyadenylation signals. These mRNAs encode six different isoforms of galectin-8: three belong to the tandem-repeat galectin group (with two CRDs linked by a hinge peptide) and three to the prototype group (with one CRD). Various studies showed that galectin-8 is widely expressed in tumor tissues as well as in normal tissues. The level of galectin-8 expression may correlate with the malignancy of human colon cancers and the degree of differentiation of lung squamous cell carcinomas and neuro-endocrine tumors. Recently, the differences in galectin-8 expression levels between normal and tumor tissues have been used as a guide for the selection of strategies for the prevention and treatment of lung squamous cell carcinoma. These experiments are still under investigation, but demonstrate the potential of galectin-8 research to enhance our understanding of, and possibly prevent, the process of neoplastic transformation.