Molecular mechanisms of protective roles of isoflavones against chemicals-induced liver injuries
Molecular mechanisms of protective roles of isoflavones against chemicals-induced liver injuries
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DOI：
10.1016/j.cbi.2020.109213
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发表时间：
2020-09-25
影响因子：
5.1
通讯作者：
Karimi-Sales, Elham
中科院分区：
文献类型：
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作者：
Alipour, Mohammad Reza;Karimi-Sales, Elham
植物雌激素是一种植物源性物质，其结构与17-β-雌二醇相似，在雌激素依赖性疾病中具有保护作用。异黄酮类化合物是植物雌激素中最著名的一类，通过多种分子机制对化学性肝损伤具有保护作用。葛根素酮的肝脏保护作用部分与其抗氧化、抗炎、免疫调节和抗纤维化特性有关。此外，芦荟酮可以减少肠道源性内毒素，加速酒精代谢，刺激肝毒性化学物质的解毒，抑制这些化学物质的生物活化，抑制肝细胞凋亡，并恢复化学物质诱导的肝脏疾病期间的自噬活性。本文综述了近年来对葛根素类化合物保肝作用的分子机制的研究进展。似乎需要进一步的研究来调查不同阶段的化学品诱导的肝损伤患者中的葛根素酮的肝保护潜力。
Phytoestrogens are plant-derived substances with a similar structure to 17-beta-estradiol, which have protective roles in estrogen-dependent diseases. Isoflavones, the most well-known subgroup of phytoestrogens, play pro-tective roles against chemicals-induced liver injuries through several molecular mechanisms. Hepatoprotective effects of isoflavones are, partly, associated with their antioxidant, anti-inflammatory, immunomodulatory, and anti-fibrotic properties. Besides, isoflavones can reduce gut-derived endotoxins, accelerate alcohol metabolism, stimulate detoxification of hepatotoxic chemicals, suppress the bioactivation of these chemicals, inhibit hepatocytes apoptosis, and restore autophagy activity during chemicals-induced liver diseases. This review provides a summary of the molecular mechanisms underlying the hepatoprotective effects of isoflavones. It seems that further studies are needed to investigate the hepatoprotective potential of isoflavones in patients with different stages of chemicals-induced liver injuries.