Sensorimotor cortex injury effects on recovery of contralesional dexterous movements in Macaca mulatta
Sensorimotor cortex injury effects on recovery of contralesional dexterous movements in Macaca mulatta
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DOI：
10.1016/j.expneurol.2016.04.004
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发表时间：
2016-07-01
影响因子：
5.3
通讯作者：
Morecraft, Robert J.
中科院分区：
文献类型：
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作者：
Darling, Warren G.;Pizzimenti, Marc A.;Morecraft, Robert J.
为探讨初级躯体感觉皮层(S1)损伤对健侧上肢伸展和抓握功能恢复的影响，比较单发于初级运动皮质(M1)臂/手区和外侧运动前皮质(LPMC)的损伤与同一区域加前顶叶皮质(S1和PE区)损伤的后果。我们使用多元线性回归来评估灰质和白质损伤体积对13只猴子损伤后第一个月和损伤后3个月、6个月和12个月功能恢复期间伸展能力和精细运动能力障碍的影响。额顶损伤的受试者表现出更大的缺陷和更差的恢复，包括一名表现出恢复迹象后出现习得性无用的广泛的罗兰迪克周围损伤的受试者。回归分析显示，白质损伤的总体积与损伤后最初的运动功能障碍以及伸展和操作技能的恢复密切相关。以尾侧M1损伤百分比(M1c)、吻侧S1损伤百分比(S1r)、LPMC和面积PE为预测变量的多元回归分析显示，S1r损伤体积与损伤后上肢功能恢复延迟和恢复技能水平降低密切相关。相比之下，Mic损伤体积主要与损伤后手运动能力的初始缺陷有关。总体而言，这些发现表明，额顶损伤对手运动功能的损害比单独的额叶运动损伤更严重，并且比仅限于额叶运动皮质的损伤导致更慢和更差的恢复。(C)2016 Elsevier Inc.保留所有权利。
The effects of primary somatosensory cortex (S1) injury on recovery of contralateral upper limb reaching and grasping were studied by comparing the consequences of isolated lesions to the arm/hand region of primary motor cortex (M1) and lateral premotor cortex (LPMC) to lesions of these same areas plus anterior parietal cortex (S1 and rostral area PE). We used multiple linear regression to assess the effects of gray and white matter lesion volumes on deficits in reaching and fine motor performance during the first month after the lesion, and during recovery of function over 3, 6 and 12 months post-injury in 13 monkeys. Subjects with frontoparietal lesions exhibited larger deficits and poorer recovery as predicted, including one subject with extensive peri-Rolandic injury developing learned nonuse after showing signs of recovery. Regression analyses showed that total white matter lesion volume was strongly associated with initial post-lesion deficits in motor performance and with recovery of skill in reaching and manipulation. Multiple regression analyses using percent damage to caudal M1 (M1c), rostral S1 (S1r), LPMC and area PE as predictor variables showed that S1r lesion volumes were closely related to delayed post-lesion recovery of upper limb function, as well as lower skill level of recovery. In contrast, Mic lesion volume was related primarily to initial post-lesion deficits in hand motor performance. Overall, these findings demonstrate that frontoparietal injury impairs hand motor function more so than frontal motor injury alone, and results in slower and poorer recovery than lesions limited to frontal motor cortex. (C) 2016 Elsevier Inc. All rights reserved.