Iatrogenic Arsenism Characterized by Palmoplantar Hyperkeratosis and Diffused Skin Cancers for Over Decades
Iatrogenic Arsenism Characterized by Palmoplantar Hyperkeratosis and Diffused Skin Cancers for Over Decades
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数十年来以掌跖角化过度和弥漫性皮肤癌为特征的医源性砷中毒
DOI：
10.1097/dad.0000000000001903
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Liangchun Wang
中科院分区：
文献类型：
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作者：
Cui-cui Tian;Feng-Qiu Hu;Sha Lu;Guo-Zhen Tan;Liangchun Wang
慢性砷中毒通常发生在长期未意识到砷暴露于环境、职业、食物和水之后。我们在此报告3例长期服用砷药物引起的弥漫性砷角化病和皮肤癌。在这些病例中，角化过度的皮肤病变最初出现在手掌和脚底，慢慢发展到皮肤的各个部位，最长持续30年以上。几十年来，皮肤癌的诊断和切除断断续续，但其他器官没有恶性肿瘤。口服类维生素a结合外用5-氟尿嘧啶和光动力治疗产生了理想的结果。
Chronic arsenism usually occurs after a long-term unawareness of arsenic exposure from environment, occupation, food, and water. We here reported 3 cases with diffused arsenic keratosis and skin cancers derived from long-term arsenic medication ingestion. In these cases, hyperkeratotic skin lesions were initially found on palms and soles, slowly progressed to every part of the skin and lasted maximally for over 30 years. Skin cancers were diagnosed and removed intermittently within decades, but with no malignancies in other organs. Oral retinoids combing with topical 5-fluorouracil and photodynamic treatment yielded a desirable outcome.