Autism prevalence in China is comparable to Western prevalence
Autism prevalence in China is comparable to Western prevalence
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DOI：
10.1186/s13229-018-0246-0
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发表时间：
2019-02-28
期刊：
影响因子：
6.2
通讯作者：
Brayne, Carol
中科院分区：
文献类型：
--
作者：
Sun, Xiang;Allison, Carrie;Brayne, Carol
背景在西方，自闭症的患病率约为学龄儿童的1%。据报道，中国的自闭症患病率低于西方。这可能是由于至少两个原因：（1）中国的大多数研究只包括特殊学校人群，忽视了主流学校人群;（2）中国的大多数研究没有使用现代筛查和诊断方法。为了解决这一问题，我们测试了总的自闭症患病率（主流和特殊学校）在吉林市，主流学校的自闭症患病率在佳木斯和深圳countries.MethodsThe study includes a three-step process：（1）筛选;（2）临床评估的屏幕阳性加控制;和（3）研究诊断评估的那些符合临床阈值的关注在第2步。每万名6- 10岁儿童的患病率估计加权的研究设计使用的诊断标准应用在research assessment stage.ResultsIn吉林市，77例自闭症被确定为总人口的7258，相当于患病率为108每万人（95%置信区间（CI）89，130）。深圳市：筛查了21，420名儿童，确定了35例自闭症病例，导致主流患病率为42/10，000（95%CI 20-89）。在佳木斯市，16，358名儿童进行了筛查，10例自闭症被确定，与主流患病率为19每10，000（95%CI 10-38）.ConclusionsResults从吉林市，其中主流和特殊学校的数据，揭示了类似的自闭症患病率在中国的西方，在1%左右。来自深圳和佳木斯市的结果，只有主流数据可用，患病率也符合西方的估计。在这三个城市，研究在主流学校发现了自闭症的新病例，反映了目前的诊断不足。不同城市之间的差异不显著，这表明有必要探索中国不同地区自闭症的潜在差异，并采用大样本量，以实现完全稳健的全国范围。
BackgroundAutism prevalence in the West is approximately 1% of school age children. Autism prevalence in China has been reported to be lower than in the West. This is likely due to at least two reasons: (1) most studies in China only included the special school population, overlooking the mainstream school population; and (2) most studies in China have not used contemporary screening and diagnostic methods. To address this, we tested total autism prevalence (mainstream and special schools) in Jilin City, and mainstream school autism prevalence in Jiamusi and Shenzhen cities.MethodsThe study included a three-step process: (1) screening; (2) clinical assessment of screen positives' plus controls; and (3) research diagnostic assessment of those meeting clinical threshold for concerns at step 2. Prevalence estimates per 10,000 children aged 6-10years old were weighted for study design using diagnostic criteria applied at the research assessment stage.ResultsIn Jilin City, 77 cases of autism were identified from a total population of 7258, equating to a prevalence of 108 per 10,000 (95% confidence interval (CI) 89, 130). In Shenzhen City: 21,420 children were screened and 35 cases of autism were identified, resulting in a mainstream prevalence of 42 per 10,000 (95% CI 20-89). In Jiamusi City, 16,358 children were screened, with 10 autism cases being identified, with a mainstream prevalence of 19 per 10,000 (95% CI 10-38).ConclusionsResults from Jilin City, where both mainstream and special school data were available, revealed a similar prevalence of autism in China to the West, at around 1%. Results from Shenzhen and Jiamusi cities, where only mainstream data were available, prevalence is also in line with Western estimates. In all three cities, new cases of autism were identified by the study in mainstream schools, reflecting current under-diagnosis. Non-significant variation across different cities is seen indicating the need to explore potential variation of autism across diverse Chinese regions with large sample sizes to achieve a fully robust national picture.