INFLUENCE OF DIAGNOSTIC RADIOIODINES ON THE UPTAKE OF ABLATIVE DOSE OF I-131
INFLUENCE OF DIAGNOSTIC RADIOIODINES ON THE UPTAKE OF ABLATIVE DOSE OF I-131
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DOI：
10.1089/thy.1994.4.49
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发表时间：
1994-03-01
期刊：
影响因子：
6.6
通讯作者：
MANATUNGA, A
中科院分区：
文献类型：
--
作者：
PARK, HM;PERKINS, OW;MANATUNGA, A
通过目视检查回顾性比较 I-131 或 I-123 诊断调查后术后甲状腺残余物和/或甲状腺癌转移对 I-131 甲状腺清除剂量的摄取。仅对那些因分化型甲状腺癌进行甲状腺切除术后诊断扫描显示有功能组织、残余物和/或转移的患者进行评估。 I-131 调查组 (n = 26) 接受了 3 至 10 mCi 的 I-131 诊断剂量。 I-123组（n=14）接受了通常诊断剂量的I-123 300μCi。两组的年龄、性别、肿瘤类型无统计学差异。通过目视检查，I-131 组 26 名患者中的 20 名患者对随后的 I-131 甲状腺清除剂量的吸收似乎受到损害，而 I-123 组 14 名患者中没有一人受到损害（p < 0.00003）。在I-131组中，存在剂量反应的建议，即，用于诊断扫描的I-131的施用活性越高，随后的甲状腺清除剂量的明显吸收减少得越多（p = 0.0007）。甲状腺残余或颈部淋巴结转移似乎比远处（肺或骨骼）转移更频繁地受到影响（p = 0.004）。这项研究表明，I-131 3 至 10 mCi“诊断”扫描剂量的吸收辐射可能会抑制碘摄取功能。在这方面，I-123 可能是放射消融治疗之前使用的更好的初始诊断剂。
The uptakes of thyroablative doses of I-131 by postoperative thyroid remnants and/or thyroid carcinoma metastases following diagnostic surveys with I-131 or I-123 were retrospectively compared by visual inspection. Only those patients with a diagnostic scan demonstrating functioning tissue, remnant, and/or metastasis, following thyroidectomy for differentiated thyroid carcinoma, were evaluated. The I-131 survey group (n = 26) had received a diagnostic dose of 3 to 10 mCi of I-131. The I-123 group (n = 14) had received the usual diagnostic dose of 300 mu Ci of I-123. Th,,ge, sex, and tumor type in the two groups were not statistically different. The uptake of the ensuing thyroablative dose of I-131 appeared, by visual inspection, to be impaired in 20 of 26 patients in the I-131 group and in none of the 14 patients in the I-123 group (p < 0.00003). In the I-131 group there was suggestion of a dose-response, that is, the higher the administered activity of I-131 for the diagnostic scan, the more reduced was the subsequent apparent uptake of the thyroablative dose (p = 0.0007). Thyroid remnants or cervical lymph node metastases appeared to be affected more frequently than were the distant (pulmonary or skeletal) metastases (p = 0.004). This study suggests that iodine uptake function may be suppressed by the absorbed radiation from the 3 to 10 mCi ''diagnostic'' scanning dose of I-131. In this regard, I-123 may be better initial diagnostic agent to be used prior to radioablation therapy.