Associations of Ionizing Radiation and Breast Cancer-Related Serum Hormone and Growth Factor Levels in Cancer-Free Female A-Bomb Survivors
Associations of Ionizing Radiation and Breast Cancer-Related Serum Hormone and Growth Factor Levels in Cancer-Free Female A-Bomb Survivors
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DOI：
10.1667/rr2631.1
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发表时间：
2011-11-01
影响因子：
3.4
通讯作者：
Nakachi, Kei
中科院分区：
文献类型：
--
作者：
Grant, Eric J.;Neriishi, Kazuo;Nakachi, Kei
格兰特，E. J.，Neriishi，K.，科隆，J.，江口，H.，Hayashi，T.，盖耶，泉，S.，Nishi，N.，兰德，C.，史蒂文斯河G.，夏普，G。B。Nakachi，K.电离辐射与乳腺癌相关的血清激素和生长因子水平在女性无癌原子弹幸存者的协会。Radiat. Res. 176，678-687（2011）。由于CT和其他放射诊断方式的广泛使用，全世界妇女的电离辐射暴露水平正在增加。暴露于电离辐射以及雌二醇和其他性激素水平升高是公认的乳腺癌风险因素，但全身辐射对无癌妇女血清激素水平的影响尚不清楚。这项研究检查了电离辐射暴露是否与血清激素水平和其他可能介导辐射相关乳腺癌风险的标志物有关。血清样本测量无癌症的妇女参加了两年一度的健康检查与广泛的过去的辐射照射水平（N = 412，年龄26-79）。这些妇女被选作对照组，从一组原子弹爆炸幸存者中进行单独的病例对照研究。结果指标包括血清总雌二醇、生物可利用雌二醇、睾酮、孕酮、催乳素、胰岛素样生长因子-1（IGF 1）、胰岛素样生长因子结合蛋白-3（IGFBP-3）和铁蛋白水平。使用重复测量回归模型拟合广义估计方程的关系进行了评估。在绝经后妇女样本中，总雌二醇和生物可利用雌二醇的几何平均血清水平随1戈伊辐射剂量增加而增加（分别为17%（1戈伊），95%CI：1%-36%和21%（1戈伊），95%CI：4%-40%），而在绝经前妇女样本中，它们则下降（分别为-11%（1Gy），95%CI：-20%-1%和-12%（1Gy），95%CI：-20%--2%）。绝经状态的相互作用是显著的（分别为P = 0.003和P < 0.001）。在绝经后样本中，睾酮水平随辐射剂量增加而增加（30.0%（1Gy），95% CI：13%-49%），而在绝经前样本中，睾酮水平略有下降（-10%（1Gy），95% CI：-19%-0%），绝经状态的相互作用显著（P < 0.001）。血清IGF 1水平随辐射剂量线性增加（11%（1Gy），95%CI：2%-18%），绝经状态有显著的相互作用（P = 0.014）。放射相关的血清雌二醇、生物可利用雌二醇、睾酮和IGF 1水平的变化在采集时根据绝经状态进行修改。血清孕酮、催乳素、IGFBP-3或铁蛋白水平与辐射无相关性。(C)2011年，辐射研究学会
Grant, E. J., Neriishi, K., Cologne, J., Eguchi, H., Hayashi, T., Geyer, S., Izumi, S., Nishi, N., Land, C., Stevens, R. G., Sharp, G. B. and Nakachi, K. Associations of Ionizing Radiation and Breast Cancer-Related Serum Hormone and Growth Factor Levels in Cancer-Free Female A-Bomb Survivors. Radiat. Res. 176, 678-687 (2011). Levels of exposure to ionizing radiation are increasing for women worldwide due to the widespread use of CT and other radiologic diagnostic modalities. Exposure to ionizing radiation as well as increased levels of estradiol and other sex hormones are acknowledged breast cancer risk factors, but the effects of whole-body radiation on serum hormone levels in cancer-free women are unknown. This study examined whether ionizing radiation exposure is associated with levels of serum hormones and other markers that may mediate radiation-associated breast cancer risk. Serum samples were measured from cancer-free women who attended biennial health examinations with a wide range of past radiation exposure levels (N = 412, ages 26-79). The women were selected as controls for separate case-control studies from a cohort of A-bomb survivors. Outcome measures included serum levels of total estradiol, bioavailable estradiol, testosterone, progesterone, prolactin, insulin-like growth factor-1 (IGF1), insulin-like growth factor-binding protein 3 (IGFBP-3), and ferritin. Relationships were assessed using repeated-measures regression models fitted with generalized estimating equations. Geometric mean serum levels of total estradiol and bioavailable estradiol increased with 1 Gy of radiation dose among samples collected from postmenopausal women (17%(1Gy), 95% CI: 1%-36% and 21%(1Gy), 95% CI: 4%-40%, respectively), while they decreased in samples collected from premenopausal women (-11%(1Gy), 95% CI: -20%-1% and -12%(1Gy), 95% CI: -20%- -2%, respectively). Interactions by menopausal status were significant (P = 0.003 and P < 0.001, respectively). Testosterone levels increased with radiation dose in postmenopausal samples (30.0%(1Gy), 95% CI: 13%-49%) while they marginally decreased in premenopausal samples (-10%(1Gy), 95% CI: -19%-0%) and the interaction by menopausal status was significant (P < 0.001). Serum levels of IGF1 increased linearly with radiation dose (11%(1Gy), 95% CI: 2%-18%) and there was a significant interaction by menopausal status (P = 0.014). Radiation-associated changes in serum levels of estradiol, bioavailable estradiol, testosterone and IGF1 were modified by menopausal status at the time of collection. No associations with radiation were observed in serum levels of progesterone, prolactin, IGFBP-3 or ferritin. (C) 2011 by Radiation Research Society