The anxiolytic effect of chronic inositol depends on the baseline level of anxiety
The anxiolytic effect of chronic inositol depends on the baseline level of anxiety
复制标题
慢性肌醇的抗焦虑作用取决于焦虑的基线水平
DOI：
10.1007/s007020050020
复制
发表时间：
2000
影响因子：
3.3
通讯作者：
C. Shoshana
中科院分区：
文献类型：
--
作者：
O. Kofman;H. Einat;H. Cohen;H. Tenne;C. Shoshana
概括。肌醇是参与信号转导的膜磷酸肌醇的前体，已被发现在临床上对许多精神疾病有效，并可逆转锂的行为影响。为了深入了解肌醇的作用机制，在动物模型中确定其功效至关重要。根据科恩等人的初步报告。 (1997b) 肌醇在高架十字迷宫焦虑模型中具有抗焦虑作用，通过四个实验测试了大鼠长期腹膜内和长期膳食肌醇给药的效果。长期注射肌醇后，闭臂和总臂进入量显着增加，但在大鼠饲料中长期给予肌醇则没有影响。因为前2个实验表明，给药方式影响对照组焦虑的控制水平（开臂进入和开臂时间），所以在暴露于轻度和更严重压力形式的大鼠中测试了长期饮食肌醇的影响。长期注射盐水会增加十字迷宫中的焦虑感，而长期饮食肌醇对这种焦虑的影响很小。给予 5% 膳食肌醇 3 周后，将大鼠预先暴露于猫。进入张开手臂的次数明显增加，表明肌醇具有抗焦虑作用。
Summary. Inositol, a precursor for membrane phosphoinositides involved in signal transduction, has been found to be clinically effective in a number of psychiatric disorders and to reverse behavioural effects of lithium. To gain insight into the mechanism of action of inositol, it is critical to establish its efficacy in animal models. Following the initial report by Cohen et al. (1997b) that inositol was anxiolytic in the elevated plus maze model of anxiety, the effect of chronic intraperitoneal and chronic dietary inositol administration in rats was tested in four experiments. There was a significant increase in closed arm and total arm entries following chronic injection of inositol, but no effect of inositol when it was given chronically in rat chow.Because the first 2 experiments suggested that the mode of drug administration affected the control levels of anxiety (open arm entries and time in open arms) in control groups, the effect of chronic dietary inositol was tested in rats that were exposed to a mild and a more severe form of stress. Chronic saline injections elevated anxiety in the plus maze, which was only marginally affected by chronic dietary inositol. Following 3 weeks administration of 5% dietary inositol rats were pre-exposed to a cat. There was a clear in-crease in number of entries into open arms, suggesting an anxiolytic effect of inositol.
胆囊收缩素八肽对新生大鼠脑细胞磷酸肌醇周转的影响。
DOI：
10.1042/bj2850847
发表时间：
1992
期刊：
The Biochemical journal
影响因子：
--
作者：
Zhang,LJ;Lu,XY;Han,JS
通讯作者：
Han,JS