Diverse Spatiotemporal Scales of Cholinergic Signaling in the Neocortex
Diverse Spatiotemporal Scales of Cholinergic Signaling in the Neocortex
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DOI：
10.1523/jneurosci.1306-19.2019
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发表时间：
2020-01-22
影响因子：
5.3
通讯作者：
Higley, Michael J.
中科院分区：
文献类型：
--
作者：
Disney, Anita A.;Higley, Michael J.
乙酰胆碱是哺乳动物中枢神经系统中的一种信号分子，对认知和行为有着广泛的影响。然而，在大脑中的胆碱能信号的性质仍然存在争议，正在进行的辩论集中在乙酰胆碱活动的空间和时间分辨率。一般来说，相反的观点已经接受了一个二分法之间的传输缓慢和体积介导与快速和突触。在这里，我们提供的观点，乙酰胆碱，像大多数其他神经递质，表现出快速和缓慢的模式，强烈决定的解剖结构的胆碱能纤维，受体亚型的分布和信号传导机制，和乙酰胆碱水解的动力学。目前的方法仍然有限，无法详细分析这些基本因素。然而，我们相信，新技术的持续发展，结合更细致入微的胆碱能活性的观点，将打开关键的新途径，以更好地了解乙酰胆碱在大脑中。
ACh is a signaling molecule in the mammalian CNS, with well-documented influence over cognition and behavior. However, the nature of cholinergic signaling in the brain remains controversial, with ongoing debates focused on the spatial and temporal resolution of ACh activity. Generally, opposing views have embraced a dichotomy between transmission as slow and volume-mediated versus fast and synaptic. Here, we provide the perspective that ACh, like most other neurotransmitters, exhibits both fast and slow modes that are strongly determined by the anatomy of cholinergic fibers, the distribution and the signaling mechanisms of receptor subtypes, and the dynamics of ACh hydrolysis. Current methodological approaches remain limited in their ability to provide detailed analyses of these underlying factors. However, we believe that the continued development of novel technologies in combination with a more nuanced view of cholinergic activity will open critical new avenues to a better understanding of ACh in the brain.