An appraisal of pediatric liver transplantation from living relatives. Initial clinical experiences in 20 pediatric liver transplantations from living relatives as donors.
An appraisal of pediatric liver transplantation from living relatives. Initial clinical experiences in 20 pediatric liver transplantations from living relatives as donors.
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对活着亲属的小儿肝移植的评估。
DOI：
10.1097/00000658-199211000-00004
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发表时间：
1992
影响因子：
9
通讯作者：
A. Tanaka
中科院分区：
文献类型：
--
作者：
K. Ozawa;S. Uemoto;Koichi Tanaka;K. Kumada;Y. Yamaoka;Nobuaki Kobayashi;T. Inamoto;Y. Shimahara;K. Mori;K. Honda;Y. Kamiyama;Hong Jin Kim;T. Morimoto;A. Tanaka
作者在1990年6月至1991年7月间进行了20例活体亲属供肝移植。20例儿童患者（14例胆道闭锁，2例Budd-Chiari综合征，1例丙型肝炎病毒感染后肝硬化（HCV肝炎），1例进行性肝内胆汁淤积症，1例肝硬化，1例原卟啉症）接受了11个左叶，8个左外侧段和1个右叶移植。捐献者的选择仅限于受者的父母。免疫抑制治疗包括FK 506和类固醇。17名受助者还活着，其中15人情况良好，在家。两名接受紧急移植的受者死于术后并发症。另一名受体在移植后6个月死于意外窒息。所有20名供体术后病程顺利，能够恢复正常的社会生活。所有病例术后2天内动脉血酮体比率（AKBR）均升高至1.0以上。只有两例ABO相容性移植物移植时发生了相对轻微的排斥反应，这些排斥反应用类固醇和FK 506成功治疗。
The authors performed 20 liver transplantations from living related donors between June 1990 and July 1991. The 20 pediatric patients (14 biliary atresia, two Budd-Chiari syndrome, one liver cirrhosis after hepatitis C viral infection (HCV hepatitis), 1 progressive intrahepatic cholestasis, 1 liver cirrhosis, 1 protoporphyria) were transplanted with 11 left lobes, eight left lateral segments, and one right lobe. The choice of donors was restricted to the parents of the recipients. The immunosuppressive treatment consisted of FK 506 and steroids. Seventeen recipients are alive, 15 of whom are well and at home. Two recipients, who underwent emergency transplantation, died of postoperative complications. Another recipient died of accidental asphyxia at 6 months after the transplantation. All 20 donors had uneventful postoperative courses and were able to resume their normal social lives. The arterial ketone body ratio (AKBR) increased to above 1.0 within 2 days after the transplantation in all cases. Relatively mild rejection episodes were encountered in only two cases transplanted with ABO-compatible grafts, and these were treated successfully with steroids and FK 506.